登録情報 | データベース: PDB / ID: 6f7i |
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タイトル | human MALT1(329-728) IN COMPLEX WITH MLT-747 |
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要素 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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キーワード | HYDROLASE / DIMER / EXOSITE BINDER |
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機能・相同性 | 機能・相同性情報
polkadots / B-1 B cell differentiation / positive regulation of T-helper 17 cell differentiation / CBM complex / regulation of T cell receptor signaling pathway / response to fungus / activation of NF-kappaB-inducing kinase activity / CLEC7A/inflammasome pathway / nuclear export / B cell activation ...polkadots / B-1 B cell differentiation / positive regulation of T-helper 17 cell differentiation / CBM complex / regulation of T cell receptor signaling pathway / response to fungus / activation of NF-kappaB-inducing kinase activity / CLEC7A/inflammasome pathway / nuclear export / B cell activation / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / small molecule binding / T cell proliferation / lipopolysaccharide-mediated signaling pathway / positive regulation of interleukin-2 production / proteolysis involved in protein catabolic process / positive regulation of interleukin-1 beta production / positive regulation of protein ubiquitination / Activation of NF-kappaB in B cells / positive regulation of T cell cytokine production / CLEC7A (Dectin-1) signaling / fibrillar center / defense response / FCERI mediated NF-kB activation / ubiquitin-protein transferase activity / : / Downstream TCR signaling / peptidase activity / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / regulation of apoptotic process / positive regulation of canonical NF-kappaB signal transduction / protease binding / endopeptidase activity / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / cysteine-type endopeptidase activity / innate immune response / negative regulation of apoptotic process / perinuclear region of cytoplasm / protein-containing complex / proteolysis / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Immunoglobulin-like - #3360 / Mucosa-associated lymphoid tissue lymphoma translocation protein 1 / MALT1, death domain / MALT1 immunoglobulin-like domain / MALT1 Ig-like domain / Rossmann fold - #1460 / Immunoglobulin domain / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : ...Immunoglobulin-like - #3360 / Mucosa-associated lymphoid tissue lymphoma translocation protein 1 / MALT1, death domain / MALT1 immunoglobulin-like domain / MALT1 Ig-like domain / Rossmann fold - #1460 / Immunoglobulin domain / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Immunoglobulin domain / Death-like domain superfamily / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Chem-CW5 / Mucosa-associated lymphoid tissue lymphoma translocation protein 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.43 Å |
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データ登録者 | Renatus, M. / Renatus, M. |
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引用 | ジャーナル: Nat. Chem. Biol. / 年: 2019 タイトル: An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. 著者: Quancard, J. / Klein, T. / Fung, S.Y. / Renatus, M. / Hughes, N. / Israel, L. / Priatel, J.J. / Kang, S. / Blank, M.A. / Viner, R.I. / Blank, J. / Schlapbach, A. / Erbel, P. / Kizhakkedathu, ...著者: Quancard, J. / Klein, T. / Fung, S.Y. / Renatus, M. / Hughes, N. / Israel, L. / Priatel, J.J. / Kang, S. / Blank, M.A. / Viner, R.I. / Blank, J. / Schlapbach, A. / Erbel, P. / Kizhakkedathu, J. / Villard, F. / Hersperger, R. / Turvey, S.E. / Eder, J. / Bornancin, F. / Overall, C.M. |
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履歴 | 登録 | 2017年12月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年1月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年2月13日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2019年2月27日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2024年5月1日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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