Entry Database : PDB / ID : 6f7b Structure visualization Downloads & linksTitle Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032 ComponentsMitotic checkpoint serine/threonine-protein kinase BUB1 Details Keywords TRANSFERASE / BUB1 / kinase inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
histone H2A kinase activity / positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric / regulation of sister chromatid cohesion / regulation of chromosome segregation / meiotic sister chromatid cohesion, centromeric / outer kinetochore / mitotic spindle assembly checkpoint signaling / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation ... histone H2A kinase activity / positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric / regulation of sister chromatid cohesion / regulation of chromosome segregation / meiotic sister chromatid cohesion, centromeric / outer kinetochore / mitotic spindle assembly checkpoint signaling / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / chromosome segregation / RHO GTPases Activate Formins / kinetochore / Separation of Sister Chromatids / non-specific serine/threonine protein kinase / protein kinase activity / phosphorylation / cell division / intracellular membrane-bounded organelle / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / nucleoplasm / ATP binding / membrane / nucleus / cytosol Similarity search - Function GTP Cyclohydrolase I; Chain A, domain 1 - #20 / GTP Cyclohydrolase I; Chain A, domain 1 / Mad3/Bub1 homology region 1 / Mitotic spindle checkpoint protein Bub1/Mad3 / Mad3/BUB1 homology region 1 / BUB1 N-terminal domain profile. / Mad3/BUB1 hoMad3/BUB1 homology region 1 / Helix non-globular / Special / Transferase(Phosphotransferase) domain 1 ... GTP Cyclohydrolase I; Chain A, domain 1 - #20 / GTP Cyclohydrolase I; Chain A, domain 1 / Mad3/Bub1 homology region 1 / Mitotic spindle checkpoint protein Bub1/Mad3 / Mad3/BUB1 homology region 1 / BUB1 N-terminal domain profile. / Mad3/BUB1 hoMad3/BUB1 homology region 1 / Helix non-globular / Special / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Holton, S.J. / Siemeister, G. / Mengel, A. / Bone, W. / Schroeder, J. / Zitzmann-Kolbe, S. / Briem, H. / Fernandez-Montalvan, A. / Prechtl, S. / Moenning, U. ...Holton, S.J. / Siemeister, G. / Mengel, A. / Bone, W. / Schroeder, J. / Zitzmann-Kolbe, S. / Briem, H. / Fernandez-Montalvan, A. / Prechtl, S. / Moenning, U. / von Ahsen, O. / Johanssen, J. / Cleve, A. / Puetter, V. / Hitchcock, M. / von Nussbaum, F. / Brands, M. / Mumberg, D. / Ziegelbauer, K. CitationJournal : Clin.Cancer Res. / Year : 2019Title : Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo.Authors: Siemeister, G. / Mengel, A. / Fernandez-Montalvan, A.E. / Bone, W. / Schroder, J. / Zitzmann-Kolbe, S. / Briem, H. / Prechtl, S. / Holton, S.J. / Monning, U. / von Ahsen, O. / Johanssen, S. ... Authors : Siemeister, G. / Mengel, A. / Fernandez-Montalvan, A.E. / Bone, W. / Schroder, J. / Zitzmann-Kolbe, S. / Briem, H. / Prechtl, S. / Holton, S.J. / Monning, U. / von Ahsen, O. / Johanssen, S. / Cleve, A. / Putter, V. / Hitchcock, M. / von Nussbaum, F. / Brands, M. / Ziegelbauer, K. / Mumberg, D. History Deposition Dec 8, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 19, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Apr 24, 2019 Group : Data collection / Database references / Category : citation / citation_author / pdbx_database_procItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 May 5, 2021 Group : Derived calculations / Category : struct_conn / struct_conn_typeItem : _struct_conn.conn_type_id / _struct_conn.id ... _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
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