登録情報 データベース : PDB / ID : 6et4 構造の表示 ダウンロードとリンクタイトル HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR 要素Dihydroorotate dehydrogenase (quinone), mitochondrial 詳細 キーワード OXIDOREDUCTASE / DHODH / CANCER / P53 ACTIVATION / PYRIMIDINE SYNTHESIS機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol 類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta 類似検索 - ドメイン・相同性 ACETIC ACID / DECYLAMINE-N,N-DIMETHYL-N-OXIDE / Chem-DOR / FLAVIN MONONUCLEOTIDE / Chem-SDV / Dihydroorotate dehydrogenase (quinone), mitochondrial 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.7 Å 詳細データ登録者 Hakansson, M. / Walse, B. / Gustavsson, A.-L. / Lain, S. 引用ジャーナル : Nat Commun / 年 : 2018タイトル : A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.著者: Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. / Nekulova, M. / Sachweh, M.C.C. ... 著者 : Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. / Nekulova, M. / Sachweh, M.C.C. / Campbell, J. / Higgins, M. / Tuck, C. / Popa, M. / Safont, M.M. / Gelebart, P. / Fandalyuk, Z. / Thompson, A.M. / Svensson, R. / Gustavsson, A.L. / Johansson, L. / Farnegardh, K. / Yngve, U. / Saleh, A. / Haraldsson, M. / D'Hollander, A.C.A. / Franco, M. / Zhao, Y. / Hakansson, M. / Walse, B. / Larsson, K. / Peat, E.M. / Pelechano, V. / Lunec, J. / Vojtesek, B. / Carmena, M. / Earnshaw, W.C. / McCarthy, A.R. / Westwood, N.J. / Arsenian-Henriksson, M. / Lane, D.P. / Bhatia, R. / McCormack, E. / Lain, S. 履歴 登録 2017年10月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年3月28日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.