Entry | Database: PDB / ID: 5hqe |
---|
Title | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with compound 18T |
---|
Components | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Keywords | OXIDOREDUCTASE/INHIBITOR / Enzyme / OXIDOREDUCTASE-INHIBITOR complex |
---|
Function / homology | Function and homology information
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / cytosolSimilarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel ...Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha BetaSimilarity search - Domain/homology Chem-64B / ACETATE ION / FLAVIN MONONUCLEOTIDE / OROTIC ACID / Dihydroorotate dehydrogenase (quinone), mitochondrialSimilarity search - Component |
---|
Biological species | Homo sapiens (human) |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.62 Å |
---|
Authors | Huang, J. / Wu, D. / Lu, Q. |
---|
Citation | Journal: To Be Published Title: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18T at 1.62 A resolution Authors: Huang, J. / Wu, D. / Lu, Q. |
---|
History | Deposition | Jan 21, 2016 | Deposition site: RCSB / Processing site: PDBJ |
---|
Revision 1.0 | Jul 27, 2016 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Mar 20, 2024 | Group: Data collection / Database references / Derived calculations Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
---|
|
---|