Entry Database : PDB / ID : 6et4 Structure visualization Downloads & linksTitle HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR ComponentsDihydroorotate dehydrogenase (quinone), mitochondrial Details Keywords OXIDOREDUCTASE / DHODH / CANCER / P53 ACTIVATION / PYRIMIDINE SYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol Similarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homology ACETIC ACID / DECYLAMINE-N,N-DIMETHYL-N-OXIDE / Chem-DOR / FLAVIN MONONUCLEOTIDE / Chem-SDV / Dihydroorotate dehydrogenase (quinone), mitochondrial Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.7 Å DetailsAuthors Hakansson, M. / Walse, B. / Gustavsson, A.-L. / Lain, S. CitationJournal : Nat Commun / Year : 2018Title : A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.Authors: Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. / Nekulova, M. / Sachweh, M.C.C. ... Authors : Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. / Nekulova, M. / Sachweh, M.C.C. / Campbell, J. / Higgins, M. / Tuck, C. / Popa, M. / Safont, M.M. / Gelebart, P. / Fandalyuk, Z. / Thompson, A.M. / Svensson, R. / Gustavsson, A.L. / Johansson, L. / Farnegardh, K. / Yngve, U. / Saleh, A. / Haraldsson, M. / D'Hollander, A.C.A. / Franco, M. / Zhao, Y. / Hakansson, M. / Walse, B. / Larsson, K. / Peat, E.M. / Pelechano, V. / Lunec, J. / Vojtesek, B. / Carmena, M. / Earnshaw, W.C. / McCarthy, A.R. / Westwood, N.J. / Arsenian-Henriksson, M. / Lane, D.P. / Bhatia, R. / McCormack, E. / Lain, S. History Deposition Oct 25, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Mar 28, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 8-STRANDED BARREL THIS IS REPRESENTED BY A 9-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.