Entry | Database: PDB / ID: 6eha |
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Title | Heme oxygenase 1 in complex with inhibitor |
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Components | Heme oxygenase 1 |
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Keywords | OXIDOREDUCTASE / heme oxygenase |
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Function / homology | Function and homology information
Regulation of HMOX1 expression and activity / heme oxygenase (biliverdin-producing) / low-density lipoprotein particle clearance / cellular response to cisplatin / heme oxidation / smooth muscle hyperplasia / heme oxygenase (decyclizing) activity / negative regulation of leukocyte migration / wound healing involved in inflammatory response / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ...Regulation of HMOX1 expression and activity / heme oxygenase (biliverdin-producing) / low-density lipoprotein particle clearance / cellular response to cisplatin / heme oxidation / smooth muscle hyperplasia / heme oxygenase (decyclizing) activity / negative regulation of leukocyte migration / wound healing involved in inflammatory response / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / heme catabolic process / cellular response to arsenic-containing substance / positive regulation of epithelial cell apoptotic process / erythrocyte homeostasis / endothelial cell proliferation / epithelial cell apoptotic process / Heme degradation / NFE2L2 regulating anti-oxidant/detoxification enzymes / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / positive regulation of cell migration involved in sprouting angiogenesis / negative regulation of macroautophagy / The NLRP3 inflammasome / positive regulation of macroautophagy / regulation of angiogenesis / Purinergic signaling in leishmaniasis infection / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of chemokine production / cellular response to cadmium ion / macroautophagy / negative regulation of smooth muscle cell proliferation / Iron uptake and transport / positive regulation of smooth muscle cell proliferation / response to nicotine / Heme signaling / response to hydrogen peroxide / Cytoprotection by HMOX1 / multicellular organismal-level iron ion homeostasis / positive regulation of angiogenesis / cellular response to heat / cellular response to hypoxia / angiogenesis / Interleukin-4 and Interleukin-13 signaling / positive regulation of canonical NF-kappaB signal transduction / intracellular iron ion homeostasis / mitochondrial outer membrane / response to oxidative stress / intracellular signal transduction / heme binding / endoplasmic reticulum membrane / regulation of transcription by RNA polymerase II / structural molecule activity / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / protein homodimerization activity / extracellular space / nucleoplasm / identical protein binding / membrane / nucleus / metal ion binding / cytosolSimilarity search - Function Haem oxygenase conserved site / Heme oxygenase signature. / Haem oxygenase / Haem oxygenase-like / Heme oxygenase / Heme oxygenase-like / Heme Oxygenase; Chain A / Haem oxygenase-like, multi-helical / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Grudnik, P. / Mieczkowski, M. |
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Citation | Journal: Arch.Biochem.Biophys. / Year: 2019 Title: Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment. Authors: Mucha, O. / Podkalicka, P. / Mikulski, M. / Barwacz, S. / Andrysiak, K. / Biela, A. / Mieczkowski, M. / Kachamakova-Trojanowska, N. / Ryszawy, D. / Bialas, A. / Szelazek, B. / Grudnik, P. / ...Authors: Mucha, O. / Podkalicka, P. / Mikulski, M. / Barwacz, S. / Andrysiak, K. / Biela, A. / Mieczkowski, M. / Kachamakova-Trojanowska, N. / Ryszawy, D. / Bialas, A. / Szelazek, B. / Grudnik, P. / Majewska, E. / Michalik, K. / Jakubiec, K. / Bien, M. / Witkowska, N. / Gluza, K. / Ekonomiuk, D. / Sitarz, K. / Galezowski, M. / Brzozka, K. / Dubin, G. / Jozkowicz, A. / Dulak, J. / Loboda, A. |
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History | Deposition | Sep 12, 2017 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Oct 10, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 23, 2019 | Group: Data collection / Database references / Structure summary Category: citation / citation_author / entity Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _entity.formula_weight |
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Revision 1.2 | May 8, 2024 | Group: Advisory / Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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