Entry Database : PDB / ID : 6dm4 Structure visualization Downloads & linksTitle Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila in complex with Homo sapiens Shc1 phospho-Tyr317 peptide ComponentsRavO Shc1 phospho-Tyr317 peptide DetailsKeywords PROTEIN BINDING / SH2 domain / Src homolog 2 domain / Shc1 / phosphopeptide binding / LEGIONELLA PNEUMOPHILA / STRUCTURAL GENOMICS / APC108076 / MIDWEST CENTER FOR STRUCTURAL GENOMICS / MCSG / PSI-BIOLOGYFunction / homology Function and homology informationFunction Domain/homology Component
regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / Interleukin-2 signaling / Shc-EGFR complex / Signaling by LTK / epidermal growth factor binding ... regulation of superoxide metabolic process / positive regulation of cell proliferation in bone marrow / XBP1(S) activates chaperone genes / neurotrophin TRKA receptor binding / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / Interleukin-2 signaling / Shc-EGFR complex / Signaling by LTK / epidermal growth factor binding / epidermal growth factor receptor binding / Signaling by ALK / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / Signalling to RAS / SHC-related events triggered by IGF1R / Role of LAT2/NTAL/LAB on calcium mobilization / Interleukin receptor SHC signaling / Signal attenuation / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / Signaling by CSF3 (G-CSF) / Tie2 Signaling / insulin-like growth factor receptor binding / SHC1 events in EGFR signaling / ephrin receptor binding / phosphotyrosine residue binding / SHC1 events in ERBB2 signaling / Integrin signaling / Constitutive Signaling by Overexpressed ERBB2 / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / negative regulation of angiogenesis / insulin-like growth factor receptor signaling pathway / FCERI mediated MAPK activation / Signaling by ERBB2 TMD/JMD mutants / insulin receptor binding / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / epidermal growth factor receptor signaling pathway / Signaling by ERBB2 KD Mutants / phospholipid binding / receptor tyrosine kinase binding / cellular response to growth factor stimulus / cell-cell adhesion / Signaling by CSF1 (M-CSF) in myeloid cells / GPER1 signaling / Signaling by ALK fusions and activated point mutants / insulin receptor signaling pathway / DAP12 signaling / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / heart development / actin cytoskeleton organization / RAF/MAP kinase cascade / angiogenesis / positive regulation of MAPK cascade / Extra-nuclear estrogen signaling / positive regulation of ERK1 and ERK2 cascade / intracellular signal transduction / mitochondrial matrix / defense response to bacterium / focal adhesion / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / plasma membrane / cytosol Similarity search - Function Phosphotyrosine interaction domain, Shc-like / SH2 adaptor protein C, SH2 domain / : / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains ... Phosphotyrosine interaction domain, Shc-like / SH2 adaptor protein C, SH2 domain / : / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / PH-like domain superfamily Similarity search - Domain/homologyBiological species Legionella pneumophila subsp. pneumophila (bacteria)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Stogios, P.J. / Evdokimova, E. / Di Leo, R. / Kaneko, T. / Li, S. / Savchenko, A. / Midwest Center for Structural Genomics (MCSG) Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM074942 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM094585 United States
CitationJournal : To Be Published Title : Crystal structure of the SH2 domain from RavO (Lpg1129) from Legionella pneumophila in complex with Homo sapiens Shc1 phospho-Tyr317 peptideAuthors : Kaneko, T. History Deposition Jun 4, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 27, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_supportItem : _pdbx_audit_support.country / _pdbx_audit_support.funding_organization
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