Entry Database : PDB / ID : 6dc0 Structure visualization Downloads & linksTitle Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron ComponentsTribbles homolog 1,CCAAT/enhancer-binding protein alpha Details Keywords SIGNALING PROTEIN / Tribbles / psuedokinase / CCAAT-enhancer binding protein / TRB1Function / homology Function and homology informationFunction Domain/homology Component
ubiquitin-protein transferase regulator activity / positive regulation of eosinophil differentiation / RNA polymerase I transcription regulatory region sequence-specific DNA binding / positive regulation of DNA-templated transcription initiation / negative regulation of smooth muscle cell migration / regulation of MAP kinase activity / granulocyte differentiation / negative regulation of neutrophil differentiation / positive regulation of macrophage differentiation / negative regulation of lipopolysaccharide-mediated signaling pathway ... ubiquitin-protein transferase regulator activity / positive regulation of eosinophil differentiation / RNA polymerase I transcription regulatory region sequence-specific DNA binding / positive regulation of DNA-templated transcription initiation / negative regulation of smooth muscle cell migration / regulation of MAP kinase activity / granulocyte differentiation / negative regulation of neutrophil differentiation / positive regulation of macrophage differentiation / negative regulation of lipopolysaccharide-mediated signaling pathway / urea cycle / negative regulation of cyclin-dependent protein serine/threonine kinase activity / myeloid cell differentiation / NGF-stimulated transcription / positive regulation of macrophage activation / positive regulation of transcription by RNA polymerase III / mitogen-activated protein kinase kinase binding / interleukin-6-mediated signaling pathway / cellular response to lithium ion / protein kinase inhibitor activity / fat cell differentiation / lipid homeostasis / transcription by RNA polymerase I / inner ear development / transcription factor binding / macrophage differentiation / cellular response to organic cyclic compound / white fat cell differentiation / embryonic placenta development / positive regulation of fat cell differentiation / positive regulation of osteoblast differentiation / brown fat cell differentiation / JNK cascade / cell maturation / Notch signaling pathway / viral process / cholesterol metabolic process / mitochondrion organization / liver development / generation of precursor metabolites and energy / negative regulation of smooth muscle cell proliferation / negative regulation of protein kinase activity / lung development / negative regulation of DNA-binding transcription factor activity / cytokine-mediated signaling pathway / kinase binding / Transcriptional regulation of white adipocyte differentiation / positive regulation of inflammatory response / Transcriptional regulation of granulopoiesis / RNA polymerase II transcription regulator complex / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / glucose homeostasis / cellular response to tumor necrosis factor / DNA-binding transcription activator activity, RNA polymerase II-specific / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / response to lipopolysaccharide / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / chromatin binding / regulation of DNA-templated transcription / chromatin / nucleolus / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function Tribbles homologue 1 / Pseudokinase tribbles family/serine-threonine-protein kinase 40 / CCAAT/enhancer-binding protein, chordates / Basic region leucine zipper / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. ... Tribbles homologue 1 / Pseudokinase tribbles family/serine-threonine-protein kinase 40 / CCAAT/enhancer-binding protein, chordates / Basic region leucine zipper / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Jamieson, S.A. / Brewster, J.L. / Mace, P.D. Funding support New Zealand, 2items Details Hide detailsOrganization Grant number Country Health Research Council (HRC) New Zealand Royal Society of New Zealand Rutherford Discovery Fellowship New Zealand
CitationJournal : Sci Signal / Year : 2018Title : Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.Authors : Jamieson, S.A. / Ruan, Z. / Burgess, A.E. / Curry, J.R. / McMillan, H.D. / Brewster, J.L. / Dunbier, A.K. / Axtman, A.D. / Kannan, N. / Mace, P.D. History Deposition May 3, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 10, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Author supporting evidence / Structure summary / Category : entity / pdbx_audit_supportItem : _entity.formula_weight / _pdbx_audit_support.funding_organizationRevision 1.2 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
Show all Show less