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TitleSubstrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.
Journal, issue, pagesSci Signal, Vol. 11, Year 2018
Publish dateMay 3, 2018 (structure data deposition date)
AuthorsJamieson, S.A. / Ruan, Z. / Burgess, A.E. / Curry, J.R. / McMillan, H.D. / Brewster, J.L. / Dunbier, A.K. / Axtman, A.D. / Kannan, N. / Mace, P.D.
External linksSci Signal / PubMed:30254053
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6dc0:
Tribbles (TRIB1) pseudokinase fused to CCAAT-enhancer binding protein (C/EBPalpha) degron
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Tribbles / psuedokinase / CCAAT-enhancer binding protein / TRB1

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