Entry Database : PDB / ID : 6cnh Structure visualization Downloads & linksTitle Human PRPF4B in complex with Rebastinib ComponentsSerine/threonine-protein kinase PRP4 homolog Details Keywords TRANSFERASE / Kinase / inhibitor / DCC2036 / Structural Genomics / Structural Genomics Consortium / SGCFunction / homology Function and homology informationFunction Domain/homology Component
regulation of mitotic cell cycle spindle assembly checkpoint / mRNA cis splicing, via spliceosome / spliceosomal tri-snRNP complex assembly / spliceosomal snRNP assembly / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / kinetochore / mRNA splicing, via spliceosome / non-specific serine/threonine protein kinase / nuclear speck ... regulation of mitotic cell cycle spindle assembly checkpoint / mRNA cis splicing, via spliceosome / spliceosomal tri-snRNP complex assembly / spliceosomal snRNP assembly / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / kinetochore / mRNA splicing, via spliceosome / non-specific serine/threonine protein kinase / nuclear speck / phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / RNA binding / nucleoplasm / ATP binding / nucleus Similarity search - Function Serine/threonine-protein PRP4, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. ... Serine/threonine-protein PRP4, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Godoi, P.H.C. / Santiago, A.S. / Ramos, P.Z. / Fala, A.M. / Salmazo, A.P.T. / Counago, R.M. / Righetto, G.L. / Silva, P.N.B. / Gileadi, O. / Guimaraes, C.R.W. ...Godoi, P.H.C. / Santiago, A.S. / Ramos, P.Z. / Fala, A.M. / Salmazo, A.P.T. / Counago, R.M. / Righetto, G.L. / Silva, P.N.B. / Gileadi, O. / Guimaraes, C.R.W. / Massirer, K.B. / Arruda, P. / Elkins, J.M. / Edwards, A.M. / Structural Genomics Consortium (SGC) Funding support Brazil, 1items Details Hide detailsOrganization Grant number Country Sao Paulo Research Foundation (FAPESP) 13/50724-5 Brazil
CitationJournal : To be Published Title : Crystal structure of the human PRPF4B in complex with RebastinibAuthors : Godoi, P.H.C. / Santiago, A.S. / Ramos, P.Z. / Silva, P.N.B. / Righetto, G.L. / Guimaraes, C.R.W. / Massirer, K.B. / Arruda, P. / Elkins, J.M. / Edwards, A.M. History Deposition Mar 8, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 28, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Apr 17, 2019 Group : Author supporting evidence / Data collection / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.3 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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