Entry Database : PDB / ID : 5awm Structure visualization Downloads & linksTitle The Crystal Structure of JNK from Drosophila melanogaster Reveals an Evolutionarily Conserved Topology with that of Mammalian JNK Proteins. ComponentsStress-activated protein kinase JNK Details Keywords TRANSFERASE / c-Jun N-terminal kinase / MAP kinase / Drosophila JNK pathwayFunction / homology Function and homology informationFunction Domain/homology Component
collateral sprouting of injured axon / Formation of the cytosolic BSK 'scaffolding complex' / Formation of the nuclear AP-1 transcription factor 'scaffolding complex' / Transcriptional activtion by AP-1 transcription factor / Imd pathway / Activation of the AP-1 family of transcription factors / Interleukin-38 signaling / NRAGE signals death through JNK / chorion micropyle formation / embryonic anterior midgut (ectodermal) morphogenesis ... collateral sprouting of injured axon / Formation of the cytosolic BSK 'scaffolding complex' / Formation of the nuclear AP-1 transcription factor 'scaffolding complex' / Transcriptional activtion by AP-1 transcription factor / Imd pathway / Activation of the AP-1 family of transcription factors / Interleukin-38 signaling / NRAGE signals death through JNK / chorion micropyle formation / embryonic anterior midgut (ectodermal) morphogenesis / dorsal closure, spreading of leading edge cells / peptidoglycan recognition protein signaling pathway / imaginal disc fusion, thorax closure / imaginal disc-derived male genitalia morphogenesis / determination of digestive tract left/right asymmetry / FCERI mediated MAPK activation / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / melanization defense response / positive regulation of neuron remodeling / dorsal closure / mushroom body development / follicle cell of egg chamber development / JUN phosphorylation / dorsal appendage formation / positive regulation of border follicle cell migration / Oxidative Stress Induced Senescence / JUN kinase activity / engulfment of apoptotic cell / cellular response to arsenic-containing substance / axon extension / wound healing, spreading of epidermal cells / MAP kinase activity / neuron development / mitogen-activated protein kinase / long-term memory / vascular endothelial growth factor receptor signaling pathway / positive regulation of autophagy / JNK cascade / tumor necrosis factor-mediated signaling pathway / cellular response to cadmium ion / neuron projection morphogenesis / axon guidance / wound healing / cellular response to reactive oxygen species / cellular response to oxidative stress / antibacterial humoral response / response to heat / regulation of gene expression / response to oxidative stress / protein kinase activity / intracellular signal transduction / axon / protein serine/threonine kinase activity / dendrite / positive regulation of gene expression / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function Mitogen-activated protein (MAP) kinase, JNK / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain ... Mitogen-activated protein (MAP) kinase, JNK / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Drosophila melanogaster (fruit fly)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.79 Å DetailsAuthors Boonserm, P. Funding support Thailand, 1items Details Hide detailsOrganization Grant number Country Mahidol University Thailand
CitationJournal : Bmc Struct.Biol. / Year : 2015Title : The crystal structure of JNK from Drosophila melanogaster reveals an evolutionarily conserved topology with that of mammalian JNK proteins.Authors : Chimnaronk, S. / Sitthiroongruang, J. / Srisucharitpanit, K. / Srisaisup, M. / Ketterman, A.J. / Boonserm, P. History Deposition Jul 6, 2015 Deposition site : PDBJ / Processing site : PDBJSupersession Aug 5, 2015 ID : 4M3A Revision 1.0 Aug 5, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Nov 11, 2015 Group : Database referencesRevision 1.2 Feb 26, 2020 Group : Data collection / Derived calculations / Category : diffrn_source / pdbx_struct_oper_listItem : _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id
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