Entry Database : PDB / ID : 6cm2 Structure visualization Downloads & linksTitle SAMHD1 HD domain bound to decitabine triphosphate ComponentsDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 Details Keywords HYDROLASE / SAMHD1 / analogues / decitabineFunction / homology Function and homology informationFunction Domain/homology Component
Nucleotide catabolism / Hydrolases; Acting on ester bonds; Triphosphoric-monoester hydrolases / deoxynucleoside triphosphate hydrolase activity / triphosphoric monoester hydrolase activity / dGTP binding / dATP catabolic process / dGTPase activity / tetraspanin-enriched microdomain / deoxyribonucleotide catabolic process / dGTP catabolic process ... Nucleotide catabolism / Hydrolases; Acting on ester bonds; Triphosphoric-monoester hydrolases / deoxynucleoside triphosphate hydrolase activity / triphosphoric monoester hydrolase activity / dGTP binding / dATP catabolic process / dGTPase activity / tetraspanin-enriched microdomain / deoxyribonucleotide catabolic process / dGTP catabolic process / DNA strand resection involved in replication fork processing / negative regulation of type I interferon-mediated signaling pathway / regulation of innate immune response / somatic hypermutation of immunoglobulin genes / RNA nuclease activity / double-strand break repair via homologous recombination / Interferon alpha/beta signaling / site of double-strand break / single-stranded DNA binding / protein homotetramerization / defense response to virus / nucleic acid binding / immune response / innate immune response / DNA damage response / GTP binding / RNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / plasma membrane Similarity search - Function : / HD domain profile. / HD domain / HD domain / SAM domain (Sterile alpha motif) / SAM domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / Sterile alpha motif. / HD/PDEase domain / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.14 Å DetailsAuthors Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. ...Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. / Wardelmann, E. / Rothenburger, T. / Mohr, S. / Scheich, S. / Comoglio, F. / Wilke, A. / Strobel, P. / Serve, H. / Michaelis, M. / Ferreiros, N. / Geisslinger, G. / Xiong, Y. / Keppler, O.T. / Cinatl, J. CitationJournal : Nat Commun / Year : 2019Title : Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.Authors: Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. / Wardelmann, E. / Rothenburger, ... Authors : Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. / Wardelmann, E. / Rothenburger, T. / Mohr, S. / Scheich, S. / Comoglio, F. / Wilke, A. / Strobel, P. / Serve, H. / Michaelis, M. / Ferreiros, N. / Geisslinger, G. / Xiong, Y. / Keppler, O.T. / Cinatl Jr., J. History Deposition Mar 2, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 19, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 1, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Oct 4, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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