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-Structure paper
Title | Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML. |
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Journal, issue, pages | Nat Commun, Vol. 10, Page 3475-3475, Year 2019 |
Publish date | Mar 2, 2018 (structure data deposition date) |
![]() | Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. ...Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. / Wardelmann, E. / Rothenburger, T. / Mohr, S. / Scheich, S. / Comoglio, F. / Wilke, A. / Strobel, P. / Serve, H. / Michaelis, M. / Ferreiros, N. / Geisslinger, G. / Xiong, Y. / Keppler, O.T. / Cinatl Jr., J. |
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Methods | X-ray diffraction |
Resolution | 2.14 Å |
Structure data | ![]() PDB-6cm2: |
Chemicals | ![]() ChemComp-F6G: ![]() ChemComp-GTP: ![]() ChemComp-MG: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / SAMHD1 / analogues / decitabine |