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Structure paper

TitleSelective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Journal, issue, pagesNat Commun, Vol. 10, Page 3475-3475, Year 2019
Publish dateMar 2, 2018 (structure data deposition date)
AuthorsOellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. ...Oellerich, T. / Schneider, C. / Thomas, D. / Knecht, K.M. / Buzovetsky, O. / Kaderali, L. / Schliemann, C. / Bohnenberger, H. / Angenendt, L. / Hartmann, W. / Wardelmann, E. / Rothenburger, T. / Mohr, S. / Scheich, S. / Comoglio, F. / Wilke, A. / Strobel, P. / Serve, H. / Michaelis, M. / Ferreiros, N. / Geisslinger, G. / Xiong, Y. / Keppler, O.T. / Cinatl Jr., J.
External linksNat Commun / PubMed:31375673
MethodsX-ray diffraction
Resolution2.14 Å
Structure data

PDB-6cm2:
SAMHD1 HD domain bound to decitabine triphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-F6G:
6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / SAMHD1 / analogues / decitabine

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