- PDB-6cgv: Revised crystal structure of human adenovirus -
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Basic information
Entry
Database: PDB / ID: 6cgv
Title
Revised crystal structure of human adenovirus
Components
(Pre-hexon-linking protein ...) x 2
Hexon protein
Hexon-interlacing protein
Penton protein
Pre-protein VI
Keywords
VIRUS / Human adenovirus Crystal structure Ad5F35 Ad35F
Function / homology
Function and homology information
hexon binding / protein transport along microtubule / viral capsid, decoration / T=25 icosahedral viral capsid / lysis of host organelle involved in viral entry into host cell / viral procapsid / microtubule-dependent intracellular transport of viral material towards nucleus / viral release from host cell / viral life cycle / host cell ...hexon binding / protein transport along microtubule / viral capsid, decoration / T=25 icosahedral viral capsid / lysis of host organelle involved in viral entry into host cell / viral procapsid / microtubule-dependent intracellular transport of viral material towards nucleus / viral release from host cell / viral life cycle / host cell / viral capsid / clathrin-dependent endocytosis of virus by host cell / host cell cytoplasm / symbiont entry into host cell / host cell nucleus / virion attachment to host cell / structural molecule activity Similarity search - Function
Pre-hexon-linking protein IIIa / Pre-hexon-linking protein IIIa / Hexon-associated protein IX / Pre-hexon-linking protein IIIa, N-terminal / Hexon-associated protein (IIIa) / Adenovirus hexon-associated protein (IX) / Pre-hexon-linking protein VIII / Adenovirus hexon associated protein, protein VIII / Adenovirus Pll, hexon, subdomain 2 / Minor capsid protein VI ...Pre-hexon-linking protein IIIa / Pre-hexon-linking protein IIIa / Hexon-associated protein IX / Pre-hexon-linking protein IIIa, N-terminal / Hexon-associated protein (IIIa) / Adenovirus hexon-associated protein (IX) / Pre-hexon-linking protein VIII / Adenovirus hexon associated protein, protein VIII / Adenovirus Pll, hexon, subdomain 2 / Minor capsid protein VI / Minor capsid protein VI / Adenovirus hexon protein / Adenovirus Pll, hexon, N-terminal / Adenovirus Pll, hexon, C-terminal / Hexon, adenovirus major coat protein, N-terminal domain / Hexon, adenovirus major coat protein, C-terminal domain / Adenovirus penton base protein / Adenovirus penton base protein / Group II dsDNA virus coat/capsid protein / Four Helix Bundle (Hemerythrin (Met), subunit A) / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
Hexon-interlacing protein / Hexon protein / Pre-hexon-linking protein IIIa / Penton protein / Pre-hexon-linking protein VIII / Pre-protein VI Similarity search - Component
Biological species
Human adenovirus C serotype 5
Method
X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 3.8 Å
#1: Journal: Proc. Natl. Acad. Sci. U.S.A. / Year: 2014 Title: Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection. Authors: Reddy, V.S. / Nemerow, G.R.
A: Hexon protein B: Hexon protein C: Hexon protein D: Hexon protein E: Hexon protein F: Hexon protein G: Hexon protein H: Hexon protein I: Hexon protein J: Hexon protein K: Hexon protein L: Hexon protein N: Penton protein M: Pre-hexon-linking protein IIIa P: Hexon-interlacing protein Q: Hexon-interlacing protein R: Hexon-interlacing protein S: Hexon-interlacing protein U: Pre-hexon-linking protein VIII V: Pre-hexon-linking protein VIII W: Pre-protein VI
A: Hexon protein B: Hexon protein C: Hexon protein D: Hexon protein E: Hexon protein F: Hexon protein G: Hexon protein H: Hexon protein I: Hexon protein J: Hexon protein K: Hexon protein L: Hexon protein N: Penton protein M: Pre-hexon-linking protein IIIa P: Hexon-interlacing protein Q: Hexon-interlacing protein R: Hexon-interlacing protein S: Hexon-interlacing protein U: Pre-hexon-linking protein VIII V: Pre-hexon-linking protein VIII W: Pre-protein VI
Idetical with deposited unit in distinct coordinate
icosahedral asymmetric unit
Type
Name
Symmetry operation
Number
point symmetry operation
1
3
A: Hexon protein B: Hexon protein C: Hexon protein D: Hexon protein E: Hexon protein F: Hexon protein G: Hexon protein H: Hexon protein I: Hexon protein J: Hexon protein K: Hexon protein L: Hexon protein N: Penton protein M: Pre-hexon-linking protein IIIa P: Hexon-interlacing protein Q: Hexon-interlacing protein R: Hexon-interlacing protein S: Hexon-interlacing protein U: Pre-hexon-linking protein VIII V: Pre-hexon-linking protein VIII W: Pre-protein VI
x 5
icosahedral pentamer
7.66 MDa, 105 polymers
Theoretical mass
Number of molelcules
Total (without water)
7,661,370
105
Polymers
7,661,370
105
Non-polymers
0
0
Water
0
Type
Name
Symmetry operation
Number
point symmetry operation
5
4
A: Hexon protein B: Hexon protein C: Hexon protein D: Hexon protein E: Hexon protein F: Hexon protein G: Hexon protein H: Hexon protein I: Hexon protein J: Hexon protein K: Hexon protein L: Hexon protein N: Penton protein M: Pre-hexon-linking protein IIIa P: Hexon-interlacing protein Q: Hexon-interlacing protein R: Hexon-interlacing protein S: Hexon-interlacing protein U: Pre-hexon-linking protein VIII V: Pre-hexon-linking protein VIII W: Pre-protein VI
x 6
icosahedral 23 hexamer
9.19 MDa, 126 polymers
Theoretical mass
Number of molelcules
Total (without water)
9,193,644
126
Polymers
9,193,644
126
Non-polymers
0
0
Water
0
Type
Name
Symmetry operation
Number
point symmetry operation
6
5
Idetical with deposited unit in distinct coordinate
icosahedral asymmetric unit, std point frame
Type
Name
Symmetry operation
Number
transform to point frame
1
6
A: Hexon protein B: Hexon protein C: Hexon protein D: Hexon protein E: Hexon protein F: Hexon protein G: Hexon protein H: Hexon protein I: Hexon protein J: Hexon protein K: Hexon protein L: Hexon protein N: Penton protein M: Pre-hexon-linking protein IIIa P: Hexon-interlacing protein Q: Hexon-interlacing protein R: Hexon-interlacing protein S: Hexon-interlacing protein U: Pre-hexon-linking protein VIII V: Pre-hexon-linking protein VIII W: Pre-protein VI
x 60
crystal asymmetric unit, crystal frame
91.9 MDa, 1260 polymers
Theoretical mass
Number of molelcules
Total (without water)
91,936,437
1260
Polymers
91,936,437
1260
Non-polymers
0
0
Water
0
Type
Name
Symmetry operation
Number
transform to crystal frame
1
point symmetry operation
60
Unit cell
Length a, b, c (Å)
854.245, 855.315, 865.907
Angle α, β, γ (deg.)
60.38, 60.43, 61.98
Int Tables number
1
Space group name H-M
P1
Symmetry
Point symmetry: (Schoenflies symbol: I (icosahedral))