登録情報 | データベース: PDB / ID: 6c7r |
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タイトル | BRD4 BD1 in complex with compound CF53 |
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要素 | Bromodomain-containing protein 4 |
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キーワード | transcription/transcription inhibitor / BROMODOMAIN / TRANSCRIPTION / transcription-transcription inhibitor complex |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
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データ登録者 | Meagher, J.L. / Stuckey, J.A. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2018 タイトル: Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. 著者: Zhao, Y. / Zhou, B. / Bai, L. / Liu, L. / Yang, C.Y. / Meagher, J.L. / Stuckey, J.A. / McEachern, D. / Przybranowski, S. / Wang, M. / Ran, X. / Aguilar, A. / Hu, Y. / Kampf, J.W. / Li, X. / ...著者: Zhao, Y. / Zhou, B. / Bai, L. / Liu, L. / Yang, C.Y. / Meagher, J.L. / Stuckey, J.A. / McEachern, D. / Przybranowski, S. / Wang, M. / Ran, X. / Aguilar, A. / Hu, Y. / Kampf, J.W. / Li, X. / Zhao, T. / Li, S. / Wen, B. / Sun, D. / Wang, S. |
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履歴 | 登録 | 2018年1月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年8月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年8月8日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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