Entry | Database: PDB / ID: 6c5x |
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Title | Crystal Structure of SOCS1 in complex with ElonginB and ElonginC |
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Components | - Elongin-B
- Elongin-C
- GP130 peptide fragment
- Suppressor of Cytokine Signalling 1
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Keywords | SIGNALING PROTEIN / Complex / Ubiquitination / Cytokine signalling / SOCS |
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Function / homology | Function and homology information
IL-6-type cytokine receptor ligand interactions / leukemia inhibitory factor receptor activity / oncostatin-M receptor activity / MAPK3 (ERK1) activation / MAPK1 (ERK2) activation / Interleukin-27 signaling / triglyceride mobilization / Interleukin-6 signaling / Interleukin-35 Signalling / oncostatin-M receptor complex ...IL-6-type cytokine receptor ligand interactions / leukemia inhibitory factor receptor activity / oncostatin-M receptor activity / MAPK3 (ERK1) activation / MAPK1 (ERK2) activation / Interleukin-27 signaling / triglyceride mobilization / Interleukin-6 signaling / Interleukin-35 Signalling / oncostatin-M receptor complex / ciliary neurotrophic factor receptor binding / regulation of type II interferon-mediated signaling pathway / interleukin-6 receptor activity / interleukin-6 binding / ciliary neurotrophic factor receptor complex / interleukin-27-mediated signaling pathway / interleukin-6 receptor complex / regulation of Notch signaling pathway / interleukin-6 receptor binding / interleukin-11-mediated signaling pathway / positive regulation of astrocyte differentiation / negative regulation of receptor signaling pathway via JAK-STAT / intestinal epithelial cell development / target-directed miRNA degradation / elongin complex / VCB complex / regulation of growth / Cul5-RING ubiquitin ligase complex / cytokine receptor activity / Cul2-RING ubiquitin ligase complex / glycogen metabolic process / neuronal cell body membrane / interleukin-6-mediated signaling pathway / positive regulation of Notch signaling pathway / negative regulation of cytosolic calcium ion concentration / protein tyrosine kinase activator activity / cytokine binding / positive regulation of smooth muscle cell migration / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / positive regulation of osteoblast differentiation / coreceptor activity / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / positive regulation of T cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / RNA Polymerase II Pre-transcription Events / transcription corepressor binding / transcription elongation by RNA polymerase II / TP53 Regulates Transcription of DNA Repair Genes / transcription initiation at RNA polymerase II promoter / Vif-mediated degradation of APOBEC3G / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / cytokine-mediated signaling pathway / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / Neddylation / cell body / ubiquitin-dependent protein catabolic process / scaffold protein binding / protein-containing complex assembly / negative regulation of neuron apoptotic process / receptor complex / protein ubiquitination / intracellular signal transduction / membrane raft / external side of plasma membrane / neuronal cell body / ubiquitin protein ligase binding / dendrite / positive regulation of cell population proliferation / regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / identical protein binding / cytoplasm / cytosolSimilarity search - Function Suppressor of cytokine signalling 1 / SOCS1, SH2 domain / SOCS box / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. / SOCS_box / Elongin C; Chain C, domain 1 ...Suppressor of cytokine signalling 1 / SOCS1, SH2 domain / SOCS box / suppressors of cytokine signalling / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. / SOCS_box / Elongin C; Chain C, domain 1 / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Immunoglobulin C2-set-like, ligand-binding / Ig-like C2-type domain / Long hematopoietin receptor, Gp130 family 2, conserved site / Long hematopoietin receptor, gp130 family signature. / Elongin B / Elongin-C / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / SKP1/BTB/POZ domain superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Ubiquitin-like (UB roll) / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Roll / Immunoglobulin-like fold / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human)
Xenopus laevis (African clawed frog) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.105 Å |
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Authors | Kershaw, N.J. / Laktyushin, A. / Babon, J.J. |
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Funding support | Australia, 1items Organization | Grant number | Country |
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Cancer Council Victoria | 1065180 | Australia |
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Citation | Journal: Nat Commun / Year: 2018 Title: The molecular basis of JAK/STAT inhibition by SOCS1. Authors: Liau, N.P.D. / Laktyushin, A. / Lucet, I.S. / Murphy, J.M. / Yao, S. / Whitlock, E. / Callaghan, K. / Nicola, N.A. / Kershaw, N.J. / Babon, J.J. |
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History | Deposition | Jan 17, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 2, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 4, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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Revision 1.2 | Nov 15, 2023 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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