+Open data
-Basic information
Entry | Database: PDB / ID: 6c5x | ||||||
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Title | Crystal Structure of SOCS1 in complex with ElonginB and ElonginC | ||||||
Components |
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Keywords | SIGNALING PROTEIN / Complex / Ubiquitination / Cytokine signalling / SOCS | ||||||
Function / homology | Function and homology information oncostatin-M receptor activity / IL-6-type cytokine receptor ligand interactions / leukemia inhibitory factor receptor activity / MAPK3 (ERK1) activation / MAPK1 (ERK2) activation / Interleukin-27 signaling / triglyceride mobilization / interleukin-6 receptor activity / interleukin-6 binding / Interleukin-6 signaling ...oncostatin-M receptor activity / IL-6-type cytokine receptor ligand interactions / leukemia inhibitory factor receptor activity / MAPK3 (ERK1) activation / MAPK1 (ERK2) activation / Interleukin-27 signaling / triglyceride mobilization / interleukin-6 receptor activity / interleukin-6 binding / Interleukin-6 signaling / Interleukin-35 Signalling / oncostatin-M receptor complex / ciliary neurotrophic factor receptor binding / regulation of type II interferon-mediated signaling pathway / ciliary neurotrophic factor receptor complex / interleukin-27-mediated signaling pathway / interleukin-6 receptor complex / regulation of Notch signaling pathway / interleukin-6 receptor binding / interleukin-11-mediated signaling pathway / protein tyrosine kinase activator activity / positive regulation of astrocyte differentiation / negative regulation of receptor signaling pathway via JAK-STAT / intestinal epithelial cell development / target-directed miRNA degradation / elongin complex / VCB complex / regulation of growth / cytokine receptor activity / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / glycogen metabolic process / interleukin-6-mediated signaling pathway / positive regulation of Notch signaling pathway / negative regulation of cytosolic calcium ion concentration / neuronal cell body membrane / positive regulation of smooth muscle cell migration / cytokine binding / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / positive regulation of osteoblast differentiation / coreceptor activity / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / positive regulation of T cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / RNA Polymerase II Pre-transcription Events / transcription corepressor binding / transcription initiation at RNA polymerase II promoter / TP53 Regulates Transcription of DNA Repair Genes / transcription elongation by RNA polymerase II / Vif-mediated degradation of APOBEC3G / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / cytokine-mediated signaling pathway / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / protein-macromolecule adaptor activity / cell body / ubiquitin-dependent protein catabolic process / scaffold protein binding / protein-containing complex assembly / negative regulation of neuron apoptotic process / receptor complex / intracellular signal transduction / protein ubiquitination / membrane raft / external side of plasma membrane / neuronal cell body / positive regulation of cell population proliferation / ubiquitin protein ligase binding / dendrite / regulation of transcription by RNA polymerase II / signal transduction / nucleoplasm / identical protein binding / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Xenopus laevis (African clawed frog) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.105 Å | ||||||
Authors | Kershaw, N.J. / Laktyushin, A. / Babon, J.J. | ||||||
Funding support | Australia, 1items
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Citation | Journal: Nat Commun / Year: 2018 Title: The molecular basis of JAK/STAT inhibition by SOCS1. Authors: Liau, N.P.D. / Laktyushin, A. / Lucet, I.S. / Murphy, J.M. / Yao, S. / Whitlock, E. / Callaghan, K. / Nicola, N.A. / Kershaw, N.J. / Babon, J.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6c5x.cif.gz | 144.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6c5x.ent.gz | 109.5 KB | Display | PDB format |
PDBx/mmJSON format | 6c5x.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6c5x_validation.pdf.gz | 475.2 KB | Display | wwPDB validaton report |
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Full document | 6c5x_full_validation.pdf.gz | 480.4 KB | Display | |
Data in XML | 6c5x_validation.xml.gz | 24.2 KB | Display | |
Data in CIF | 6c5x_validation.cif.gz | 32.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/c5/6c5x ftp://data.pdbj.org/pub/pdb/validation_reports/c5/6c5x | HTTPS FTP |
-Related structure data
Related structure data | 6c7yC 2c9wS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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