Entry | Database: PDB / ID: 6br4 |
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Title | Crystal structure of Escherichia coli DsbA in complex with {N}-methyl-1-(3-thiophen-2-ylphenyl)methanamine |
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Components | Thiol:disulfide interchange protein DsbA |
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Keywords | OXIDOREDUCTASE / disulphide catalysts / thiol oxidase / virulence factor foldase |
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Function / homology | Function and homology information
cellular response to antibiotic / protein disulfide isomerase activity / protein-disulfide reductase activity / outer membrane-bounded periplasmic spaceSimilarity search - Function Thiol:disulphide interchange protein DsbA/DsbL / DSBA-like thioredoxin domain / DSBA-like thioredoxin domain / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily ...Thiol:disulphide interchange protein DsbA/DsbL / DSBA-like thioredoxin domain / DSBA-like thioredoxin domain / Thioredoxin, conserved site / Thioredoxin family active site. / Thioredoxin domain profile. / Thioredoxin domain / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Escherichia coli (E. coli) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.99 Å |
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Authors | Heras, B. / Totsika, M. / Paxman, J.J. / Wang, G. / Scanlon, M.J. / Martin, J.L. |
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Funding support | Australia, 3items Organization | Grant number | Country |
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Australian Research Council (ARC) | DP150102287 | Australia | Australian Research Council (ARC) | FT130100580 | Australia | Australian Synchrotron Research Program Fellowship | | Australia |
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Citation | #1: Journal: Angew. Chem. Int. Ed. Engl. / Year: 2015Title: Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA. Authors: Adams, L.A. / Sharma, P. / Mohanty, B. / Ilyichova, O.V. / Mulcair, M.D. / Williams, M.L. / Gleeson, E.C. / Totsika, M. / Doak, B.C. / Caria, S. / Rimmer, K. / Horne, J. / Shouldice, S.R. / ...Authors: Adams, L.A. / Sharma, P. / Mohanty, B. / Ilyichova, O.V. / Mulcair, M.D. / Williams, M.L. / Gleeson, E.C. / Totsika, M. / Doak, B.C. / Caria, S. / Rimmer, K. / Horne, J. / Shouldice, S.R. / Vazirani, M. / Headey, S.J. / Plumb, B.R. / Martin, J.L. / Heras, B. / Simpson, J.S. / Scanlon, M.J. |
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History | Deposition | Nov 29, 2017 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Dec 27, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 14, 2018 | Group: Database references / Category: citation / Item: _citation.title / _citation.year |
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Revision 1.2 | Aug 8, 2018 | Group: Data collection / Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.3 | Jan 1, 2020 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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