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- PDB-6bna: BINDING OF AN ANTITUMOR DRUG TO DNA. NETROPSIN AND C-G-C-G-A-A-T-... -
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Open data
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Basic information
Entry | Database: PDB / ID: 6bna | ||||||||||||||||||
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Title | BINDING OF AN ANTITUMOR DRUG TO DNA. NETROPSIN AND C-G-C-G-A-A-T-T-BRC-G-C-G | ||||||||||||||||||
![]() | DNA (5'-D(*![]() DNA / B-DNA / DOUBLE HELIX / COMPLEXED WITH DRUG / MODIFIED | Function / homology | NETROPSIN / DNA / DNA (> 10) | ![]() Method | ![]() ![]() Kopka, M.L. / Yoon, C. / Goodsell, D. / Pjura, P. / Dickerson, R.E. | ![]() ![]() Title: Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G. Authors: Kopka, M.L. / Yoon, C. / Goodsell, D. / Pjura, P. / Dickerson, R.E. #1: ![]() Title: The Binding of Netropsin to Double-Helical B-DNA of Sequence C-G-C-G-A-A-T-T-BrC-G-C-G. Single Crystal X-Ray Structure Analysis Authors: Kopka, M.L. / Pjura, P. / Yoon, C. / Goodsell, D. / Dickerson, R.E. #2: ![]() Title: The Molecular Origin of DNA-Drug Specificity in Netropsin and Distamycin Authors: Kopka, M.L. / Yoon, C. / Goodsell, D. / Pjura, P. / Dickerson, R.E. History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 27.9 KB | Display | ![]() |
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PDB format | ![]() | 17.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: DNA chain | Mass: 3742.288 Da / Num. of mol.: 2 / Source method: obtained synthetically #2: Chemical | ChemComp-NT / | #3: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.04 Å3/Da / Density % sol: 39.76 % | |||||||||||||||||||||||||||||||||||
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Crystal grow | Temperature: 277 K / Method: vapor diffusion / Details: VAPOR DIFFUSION, temperature 277.00K | |||||||||||||||||||||||||||||||||||
Components of the solutions |
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Crystal grow | *PLUS Temperature: 4 ℃ | |||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Detector | Detector: DIFFRACTOMETER |
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Radiation | Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Highest resolution: 2.2 Å / Num. obs: 3240 |
Reflection | *PLUS Highest resolution: 2.2 Å |
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Processing
Software | Name: JACK-LEVITT / Classification: refinement | ||||||||||||
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Refinement | Resolution: 2.21→8 Å / σ(F): 2 /
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Refine Biso |
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Refinement step | Cycle: LAST / Resolution: 2.21→8 Å
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Refinement | *PLUS Highest resolution: 2.21 Å / Lowest resolution: 8 Å / Num. reflection all: 3140 / σ(F): 2 / Rfactor all: 0.257 | ||||||||||||
Solvent computation | *PLUS | ||||||||||||
Displacement parameters | *PLUS |