登録情報 データベース : PDB / ID : 6arj 構造の表示 ダウンロードとリンクタイトル Crystal structure of CARM1 with EPZ022302 and SAH 要素Histone-arginine methyltransferase CARM1 詳細 キーワード TRANSFERASE / protein-inhibitor complex / protein arginine methyltransferase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity ... histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity / positive regulation of epithelial cell apoptotic process / histone methyltransferase activity / positive regulation of transcription by RNA polymerase I / nuclear replication fork / positive regulation of fat cell differentiation / response to cAMP / RORA activates gene expression / Regulation of lipid metabolism by PPARalpha / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / lysine-acetylated histone binding / Heme signaling / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / RMTs methylate histone arginines / beta-catenin binding / Transcriptional regulation of white adipocyte differentiation / Circadian Clock / DNA-binding transcription factor binding / methylation / Estrogen-dependent gene expression / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / positive regulation of cell population proliferation / regulation of DNA-templated transcription / nucleoplasm / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily ... Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Chem-BW4 / S-ADENOSYL-L-HOMOCYSTEINE / Histone-arginine methyltransferase CARM1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.92 Å 詳細データ登録者 Boriack-Sjodin, P.A. / Jin, L. 引用ジャーナル : Sci Rep / 年 : 2017タイトル : Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.著者: Drew, A.E. / Moradei, O. / Jacques, S.L. / Rioux, N. / Boriack-Sjodin, A.P. / Allain, C. / Scott, M.P. / Jin, L. / Raimondi, A. / Handler, J.L. / Ott, H.M. / Kruger, R.G. / McCabe, M.T. / ... 著者 : Drew, A.E. / Moradei, O. / Jacques, S.L. / Rioux, N. / Boriack-Sjodin, A.P. / Allain, C. / Scott, M.P. / Jin, L. / Raimondi, A. / Handler, J.L. / Ott, H.M. / Kruger, R.G. / McCabe, M.T. / Sneeringer, C. / Riera, T. / Shapiro, G. / Waters, N.J. / Mitchell, L.H. / Duncan, K.W. / Moyer, M.P. / Copeland, R.A. / Smith, J. / Chesworth, R. / Ribich, S.A. 履歴 登録 2017年8月22日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2018年2月7日 Provider : repository / タイプ : Initial release改定 1.1 2024年3月13日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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