- PDB-6aci: Crystal structure of EPEC effector NleB in complex with FADD deat... -
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Basic information
Entry
Database: PDB / ID: 6aci
Title
Crystal structure of EPEC effector NleB in complex with FADD death domain
Components
FAS-associated death domain protein
T3SS secreted effector NleB homolog
Keywords
TOXIN / glycosyltransferase
Function / homology
Function and homology information
protein-arginine N-acetylglucosaminyltransferase activity / positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation / negative regulation of activation-induced cell death of T cells / death effector domain binding / symbiont-mediated suppression of host defense-related programmed cell death / FasL/ CD95L signaling / tumor necrosis factor receptor superfamily binding / symbiont-mediated suppression of host NF-kappaB cascade / TRAIL signaling / CD95 death-inducing signaling complex ...protein-arginine N-acetylglucosaminyltransferase activity / positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation / negative regulation of activation-induced cell death of T cells / death effector domain binding / symbiont-mediated suppression of host defense-related programmed cell death / FasL/ CD95L signaling / tumor necrosis factor receptor superfamily binding / symbiont-mediated suppression of host NF-kappaB cascade / TRAIL signaling / CD95 death-inducing signaling complex / ripoptosome / TRAIL-activated apoptotic signaling pathway / death-inducing signaling complex assembly / Defective RIPK1-mediated regulated necrosis / TRIF-mediated programmed cell death / TLR3-mediated TICAM1-dependent programmed cell death / Regulation by c-FLIP / CASP8 activity is inhibited / Dimerization of procaspase-8 / positive regulation of adaptive immune response / Caspase activation via Death Receptors in the presence of ligand / positive regulation of macrophage differentiation / necroptotic signaling pathway / caspase binding / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / death-inducing signaling complex / receptor serine/threonine kinase binding / negative regulation of necroptotic process / activation of cysteine-type endopeptidase activity / positive regulation of innate immune response / positive regulation of type I interferon-mediated signaling pathway / tumor necrosis factor receptor binding / death receptor binding / positive regulation of extrinsic apoptotic signaling pathway / motor neuron apoptotic process / TNFR1-induced proapoptotic signaling / RIPK1-mediated regulated necrosis / Transferases; Glycosyltransferases; Hexosyltransferases / positive regulation of activated T cell proliferation / positive regulation of execution phase of apoptosis / T cell homeostasis / positive regulation of proteolysis / behavioral response to cocaine / extrinsic apoptotic signaling pathway via death domain receptors / lymph node development / signaling adaptor activity / extrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / spleen development / thymus development / kidney development / positive regulation of interleukin-8 production / apoptotic signaling pathway / Regulation of TNFR1 signaling / Regulation of necroptotic cell death / cytoplasmic side of plasma membrane / cellular response to mechanical stimulus / positive regulation of T cell mediated cytotoxicity / positive regulation of tumor necrosis factor production / positive regulation of type II interferon production / manganese ion binding / toxin activity / cell body / T cell differentiation in thymus / positive regulation of canonical NF-kappaB signal transduction / defense response to virus / protease binding / host cell cytoplasm / molecular adaptor activity / positive regulation of apoptotic process / innate immune response / apoptotic process / protein-containing complex binding / positive regulation of transcription by RNA polymerase II / extracellular region / identical protein binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
: / FADD / Death effector domain / Death effector domain / Death effector domain (DED) profile. / Death effector domain / Death Domain, Fas / Death Domain, Fas / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). ...: / FADD / Death effector domain / Death effector domain / Death effector domain (DED) profile. / Death effector domain / Death Domain, Fas / Death Domain, Fas / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Death-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
: / URIDINE-5'-DIPHOSPHATE / Protein-arginine N-acetylglucosaminyltransferase NleB1 / FAS-associated death domain protein Similarity search - Component
Biological species
Escherichia coli O127:H6 (bacteria) Homo sapiens (human)
Mass: 35105.441 Da / Num. of mol.: 1 / Mutation: K115A Source method: isolated from a genetically manipulated source Source: (gene. exp.) Escherichia coli O127:H6 (bacteria) / Strain: E2348/69 / EPEC / Gene: E2348C_3231 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / References: UniProt: B7UI21
#2: Protein
FAS-associateddeathdomainprotein / FAS-associating death domain-containing protein / Growth-inhibiting gene 3 protein / Mediator of ...FAS-associating death domain-containing protein / Growth-inhibiting gene 3 protein / Mediator of receptor induced toxicity / Protein FADD
Mass: 10614.023 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: FADD, MORT1, GIG3 / Plasmid: pGEX6p / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / References: UniProt: Q13158
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