Entry Database : PDB / ID : 6a8o Structure visualization Downloads & linksTitle Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16 ComponentsPlasma kallikrein peptide inhibitor, DetailsKeywords HYDROLASE / serine protease / murine plasma kallikreinFunction / homology Function and homology informationFunction Domain/homology Component
Intrinsic Pathway of Fibrin Clot Formation / Activation of Matrix Metalloproteinases / plasma kallikrein / blood coagulation, intrinsic pathway / positive regulation of fibrinolysis / zymogen activation / plasminogen activation / fibrinolysis / inflammatory response / serine-type endopeptidase activity ... Intrinsic Pathway of Fibrin Clot Formation / Activation of Matrix Metalloproteinases / plasma kallikrein / blood coagulation, intrinsic pathway / positive regulation of fibrinolysis / zymogen activation / plasminogen activation / fibrinolysis / inflammatory response / serine-type endopeptidase activity / proteolysis / extracellular space Similarity search - Function Apple domain. / Apple domain / APPLE domain / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. ... Apple domain. / Apple domain / APPLE domain / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Synthemiopsis (insect)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.77 Å DetailsAuthors Xu, M. / Jiang, L. / Huang, M. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31370737, 31400637, 31170707, 31570745, 31670739, 21603033, U1405229 China
CitationJournal : Febs Lett. / Year : 2018Title : Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.Authors : Xu, M. / Chen, Y. / Xu, P. / Andreasen, P.A. / Jiang, L. / Li, J. / Huang, M. History Deposition Jul 9, 2018 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jul 10, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 29, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jul 29, 2020 Group : Data collection / Derived calculations / Structure summaryCategory : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 1.3 Nov 22, 2023 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less