PDB-6a3v: Complex structure of human 4-1BB and 4-1BBL

ID or keywords:

Entry

Database: PDB / ID: 6a3v

Title

Complex structure of human 4-1BB and 4-1BBL

Components

Tumor necrosis factor ligand superfamily member 9
Tumor necrosis factor receptor superfamily member 9

Keywords

IMMUNE SYSTEM / complex structure / agonist monoclonal antibody / cross-linking

Function / homology

Function and homology information

tumor necrosis factor receptor superfamily binding / positive regulation of cytotoxic T cell differentiation / TNFs bind their physiological receptors / regulation of immature T cell proliferation in thymus / tumor necrosis factor receptor binding / regulation of T cell proliferation / positive regulation of activated T cell proliferation / cytokine activity / cell-cell signaling / signaling receptor activity ...
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 3.391 Å

Authors

Li, Y. / Zhang, C. / Chai, Y. / Qi, J. / Tien, P. / Gao, S. / Gao, G.F.

Citation

Journal: Cell Rep / Year: 2018
Title: Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Authors: Li, Y. / Tan, S. / Zhang, C. / Chai, Y. / He, M. / Zhang, C.W. / Wang, Q. / Tong, Z. / Liu, K. / Lei, Y. / Liu, W.J. / Liu, Y. / Tian, Z. / Cao, X. / Yan, J. / Qi, J. / Tien, P. / Gao, S. / Gao, G.F.

History

Deposition	Jun 17, 2018	Deposition site: PDBJ / Processing site: PDBJ
Revision 1.0	Oct 10, 2018	Provider: repository / Type: Initial release
Revision 1.1	Apr 24, 2019	Group: Data collection / Database references / Structure summary Category: citation / citation_author / entity Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _entity.formula_weight
Revision 1.2	Jul 29, 2020	Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 1.3	Nov 22, 2023	Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Structure viewer	Molecule: MolmilJmol/JSmol

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Validation report

Summary document	6a3v_validation.pdf.gz	671.3 KB	Display	wwPDB validaton report
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Data in XML	6a3v_validation.xml.gz	114.3 KB	Display
Data in CIF	6a3v_validation.cif.gz	149.1 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/a3/6a3v ftp://data.pdbj.org/pub/pdb/validation_reports/a3/6a3v	HTTPS FTP

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Related structure data

Related structure data	6a3wC 5l36S S: Starting model for refinement C: citing same article (ref.)
Similar structure data	5eyo-1 6y6q-d 2q5w-1 5ljx-d 5lk1-d 5gnj-3 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

Related structure data

6a3wC

5l36S

S: Starting model for refinement

C: citing same article (ref.)

Similar structure data

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#68 - Aug 2005 Neurotrophins similarity (5) #126 - Jun 2010 Epidermal Growth Factor similarity (1) #182 - Feb 2015 Insulin receptor similarity (1) #184 - Apr 2015 Glucagon similarity (1)

Deposited unit

A: Tumor necrosis factor ligand superfamily member 9

B: Tumor necrosis factor receptor superfamily member 9

C: Tumor necrosis factor ligand superfamily member 9

D: Tumor necrosis factor receptor superfamily member 9

E: Tumor necrosis factor ligand superfamily member 9

F: Tumor necrosis factor receptor superfamily member 9

G: Tumor necrosis factor ligand superfamily member 9

H: Tumor necrosis factor receptor superfamily member 9

I: Tumor necrosis factor ligand superfamily member 9

J: Tumor necrosis factor receptor superfamily member 9

K: Tumor necrosis factor ligand superfamily member 9

L: Tumor necrosis factor receptor superfamily member 9

M: Tumor necrosis factor ligand superfamily member 9

N: Tumor necrosis factor receptor superfamily member 9

O: Tumor necrosis factor ligand superfamily member 9

P: Tumor necrosis factor receptor superfamily member 9

Q: Tumor necrosis factor ligand superfamily member 9

R: Tumor necrosis factor receptor superfamily member 9

S: Tumor necrosis factor ligand superfamily member 9

T: Tumor necrosis factor receptor superfamily member 9

U: Tumor necrosis factor ligand superfamily member 9

V: Tumor necrosis factor receptor superfamily member 9

W: Tumor necrosis factor ligand superfamily member 9

X: Tumor necrosis factor receptor superfamily member 9

hetero molecules

471 kDa, 24 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Tumor necrosis factor ligand superfamily member 9

B: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
Evidence: gel filtration
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Tumor necrosis factor ligand superfamily member 9

D: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

3

E: Tumor necrosis factor ligand superfamily member 9

F: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

4

G: Tumor necrosis factor ligand superfamily member 9

H: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

5

I: Tumor necrosis factor ligand superfamily member 9

J: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

6

K: Tumor necrosis factor ligand superfamily member 9

L: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

7

M: Tumor necrosis factor ligand superfamily member 9

N: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

8

O: Tumor necrosis factor ligand superfamily member 9

P: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

9

Q: Tumor necrosis factor ligand superfamily member 9

R: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

10

S: Tumor necrosis factor ligand superfamily member 9

T: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

11

U: Tumor necrosis factor ligand superfamily member 9

V: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

12

W: Tumor necrosis factor ligand superfamily member 9

X: Tumor necrosis factor receptor superfamily member 9

hetero molecules

defined by author&software
39.3 kDa, 2 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	126.091, 137.195, 140.318
Angle α, β, γ (deg.)	90.00, 111.80, 90.00
Int Tables number	4
Space group name H-M	P12₁1

#1: Protein

Tumor necrosis factor ligand superfamily member 9 / 4-1BB ligand / 4-1BBL

Mass: 21517.334 Da / Num. of mol.: 12
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Gene: TNFSF9 / Production host:

Baculovirus transfer vector pFASTBAC1 / References: UniProt: P41273

#2: Protein

Tumor necrosis factor receptor superfamily member 9 / 4-1BB ligand receptor / CDw137 / T-cell antigen 4-1BB homolog / T-cell antigen ILA

Mass: 17523.689 Da / Num. of mol.: 12
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Homo sapiens (human) / Gene: TNFRSF9, CD137, ILA / Production host:

Baculovirus transfer vector pFASTBAC1 / References: UniProt: Q07011

#3: Sugar

ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE

Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 12
Source method: isolated from a genetically manipulated source
Formula: C₈H₁₅NO₆

Identifier	Type	Program
DGlcpNAcb	CONDENSED IUPAC CARBOHYDRATE SYMBOL	GMML 1.0
N-acetyl-b-D-glucopyranosamine	COMMON NAME	GMML 1.0
b-D-GlcpNAc	IUPAC CARBOHYDRATE SYMBOL	PDB-CARE 1.0
GlcNAc	SNFG CARBOHYDRATE SYMBOL	GMML 1.0

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.41 Å³/Da / Density % sol: 48.86 %
Crystal grow	Temperature: 291 K / Method: vapor diffusion, sitting drop Details: 0.2M sodium iodide, 0.1M Bis Tris propane, pH 7.5, 20% w/v PEG 3350

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: SSRF / Beamline: BL19U1 / Wavelength: 0.9789 Å
Detector	Type: DECTRIS PILATUS3 S 6M / Detector: PIXEL / Date: Feb 4, 2017
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.9789 Å / Relative weight: 1
Reflection	Resolution: 3.391→44.666 Å / Num. obs: 60878 / % possible obs: 98.82 % / Redundancy: 3.4 % / R_pim(I) all: 0.121 / Net I/σ(I): 10.7
Reflection shell	Resolution: 3.4→3.52 Å

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Processing

Software

Name	Version	Classification
PHENIX	(1.12_2829: ???)	refinement
HKL-2000		data reduction
HKL-2000		data scaling
PHASER		phasing

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 5L36

5l36

Resolution: 3.391→44.666 Å / SU ML: 0.46 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 30.36 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.293	3099	5.09 %
R_work	0.2635	-	-
obs	0.265	60878	98.82 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Refinement step

Cycle: LAST / Resolution: 3.391→44.666 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	24905	0	168	0	25073

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.003	25647
X-RAY DIFFRACTION	f_angle_d	0.691	34726
X-RAY DIFFRACTION	f_dihedral_angle_d	21.688	9605
X-RAY DIFFRACTION	f_chiral_restr	0.043	3856
X-RAY DIFFRACTION	f_plane_restr	0.005	4541

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
3.3914-3.4443	0.3529	125	0.3423	2389	X-RAY DIFFRACTION	90
3.4443-3.5008	0.3725	160	0.3386	2624	X-RAY DIFFRACTION	100
3.5008-3.5611	0.3649	155	0.3244	2636	X-RAY DIFFRACTION	100
3.5611-3.6259	0.3673	129	0.3204	2647	X-RAY DIFFRACTION	100
3.6259-3.6956	0.2959	135	0.2964	2626	X-RAY DIFFRACTION	100
3.6956-3.771	0.3074	142	0.2803	2644	X-RAY DIFFRACTION	100
3.771-3.8529	0.3177	138	0.2805	2635	X-RAY DIFFRACTION	100
3.8529-3.9425	0.3023	146	0.2863	2656	X-RAY DIFFRACTION	100
3.9425-4.041	0.3116	152	0.2789	2605	X-RAY DIFFRACTION	99
4.041-4.1502	0.336	130	0.2573	2640	X-RAY DIFFRACTION	100
4.1502-4.2722	0.2552	142	0.2463	2628	X-RAY DIFFRACTION	99
4.2722-4.41	0.2384	148	0.2233	2641	X-RAY DIFFRACTION	99
4.41-4.5675	0.2508	114	0.2329	2670	X-RAY DIFFRACTION	99
4.5675-4.7502	0.2308	148	0.2159	2606	X-RAY DIFFRACTION	100
4.7502-4.9661	0.2527	125	0.2272	2676	X-RAY DIFFRACTION	100
4.9661-5.2275	0.2831	150	0.2402	2642	X-RAY DIFFRACTION	100
5.2275-5.5545	0.2537	144	0.2628	2616	X-RAY DIFFRACTION	99
5.5545-5.9824	0.3033	135	0.2628	2694	X-RAY DIFFRACTION	99
5.9824-6.5828	0.3197	129	0.2873	2603	X-RAY DIFFRACTION	98
6.5828-7.5314	0.3257	171	0.2746	2600	X-RAY DIFFRACTION	98
7.5314-9.4738	0.2784	145	0.2471	2642	X-RAY DIFFRACTION	99
9.4738-44.6694	0.2791	136	0.2434	2659	X-RAY DIFFRACTION	97

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.1267	-0.0249	-0.0101	0.1584	-0.0606	0.0944	0.012	-0.2809	0.2458	0.0074	-0.072	-0.1362	-0.0744	0.0587	-0.0037	0.189	-0.0008	0.0324	0.1802	-0.0362	0.2304	459.3347	74.2004	439.9867
2	0.0387	0.0539	-0.0183	0.0534	-0.016	0.0037	-0.0038	-0.3686	0.1298	0.0655	0.069	-0.0152	-0.0078	0.1895	0.0036	0.2367	0.0711	-0.0256	0.4561	-0.1078	0.27	440.4702	84.8099	461.1162
3	0.0881	0.0676	0.0021	0.0692	0.0428	0.1099	-0.0573	-0.0773	-0.1147	-0.048	-0.0515	-0.0287	0.0278	-0.075	-0.2373	0.2477	0.1458	0.023	0.01	0.1734	-0.0054	453.1187	54.8631	428.3575
4	0.9218	-0.2236	0.0829	0.3226	-0.0732	0.0885	0.057	0.0377	0.4134	-0.0722	-0.0913	-0.1976	0.0378	-0.0004	-0.0095	0.2555	0.0795	0.0846	0.2596	0.0852	0.1908	442.0223	77.1918	413.0448
5	0.0228	-0.0293	0.0005	0.056	-0.0357	0.0239	-0.0688	-0.192	-0.1056	0.1115	0.02	0.0025	0.0705	0.0539	0.0533	0.0558	0.1145	-0.0601	0.2587	0.3739	0.0035	451.643	55.21	451.507
6	0.0176	-0.0068	-0.0188	0.0074	-0.0098	0.0129	-0.1368	0.0339	-0.1282	-0.0443	0.0033	0.173	0.0482	-0.0247	-0.0005	0.3187	0.0496	0.0678	0.3717	0.0909	0.5346	427.4697	41.8284	442.7814
7	0.024	-0.0184	0.0433	0.2585	0.0344	0.1716	0.0493	0.0154	-0.0038	0.0171	-0.0928	-0.0046	-0.0035	-0.0492	-0.0733	0.1607	0.0373	0.0097	0.1766	-0.1245	0.1822	487.2402	25.1023	421.3301
8	0.0891	-0.0596	0.0438	0.1285	-0.0393	0.0626	0.0471	-0.0169	0.1788	0.0934	-0.0304	-0.132	-0.0734	0.1955	-0.1348	0.134	0.15	0.1748	0.1729	-0.1725	0.5741	512.1344	39.4743	419.1351
9	0.08	0.0314	-0.05	0.0779	-0.0893	0.111	-0.009	0.0188	0.1699	-0.1942	0.0401	-0.0245	-0.0201	0.035	-0.0018	0.3242	0.0316	0.0439	0.0898	-0.0172	0.2591	490.4246	28.4729	398.4579
10	0.0157	-0.0448	-0.026	0.0386	0.0975	0.0757	0.1435	0.1438	-0.0164	-0.0895	-0.0481	-0.0305	0.0562	-0.1104	0	0.3785	0.0404	0.0133	0.3686	-0.0117	0.2509	508.0269	6.577	383.3404
11	0.1768	0.0437	-0.1456	0.0797	0.0581	0.3783	-0.0558	0.0397	-0.0453	0.1038	-0.1222	0.0162	0.1113	-0.1525	-0.0385	0.2402	-0.0269	-0.0455	0.1194	-0.029	0.3325	482.1378	8.0014	406.3921
12	0.033	-0.0524	-0.0555	-0.0062	0.0365	0.0982	0.0492	-0.2356	-0.2824	0.123	-0.0444	0.0682	-0.0131	0.0515	0	0.2826	0.0107	0.0927	0.5536	0.1622	0.5234	495.7636	-4.599	428.9569
13	0.0687	0.0397	0.002	0.1325	0.0015	0.2136	0.1124	-0.0934	-0.0925	0.1172	-0.0271	-0.0641	0.0103	0.0511	0.1834	0.3368	-0.124	-0.0792	0.173	0.1236	0.165	466.482	56.4096	508.4135
14	0.5546	-0.0821	-0.0278	0.1665	-0.0001	0.1001	0.0306	-0.0566	0.1261	0.1129	-0.0094	0.0163	-0.018	-0.2553	-0.0267	0.3163	-0.0362	0.1486	0.4475	0.0113	0.1744	477.3227	77.5245	525.4007
15	0.05	-0.0212	0.0173	0.1582	-0.0067	0.1394	0.0571	0.1147	0.0626	0.0503	-0.0807	0.0221	0.0398	-0.0485	-0.0958	0.2706	-0.0615	0.014	0.24	0.1553	0.2884	459.6307	76.4532	498.3927
16	0.1028	0.0764	-0.0298	0.0305	0.0526	0.1443	-0.1929	0.2587	0.0866	-0.1334	0.133	-0.0249	-0.124	0.0057	-0.0052	0.2615	-0.0629	-0.0457	0.5039	0.2176	0.3245	478.7543	87.8955	477.7256
17	0.1036	0.0365	-0.0912	0.3003	-0.0644	0.1335	0.02	0.1724	-0.058	-0.0703	0.1323	-0.1562	0.1763	-0.1563	0.2057	0.1814	-0.0234	-0.0339	0.2952	-0.0753	0.1352	468.1158	58.6661	485.3189
18	0.0505	0.0292	0.0123	0.0193	-0.0032	0.0443	0.0239	-0.1069	-0.2652	0.1352	0.0712	-0.0438	0.1857	0.1091	-0.0011	0.4681	0.017	0.0914	0.289	-0.0458	0.6813	492.5981	44.8729	493.1859
19	0.1902	-0.0174	0.0763	0.1364	-0.0658	0.0919	0.1395	-0.1367	-0.0113	-0.1095	0.0207	-0.0298	-0.0566	-0.0496	0.0789	0.2135	-0.0045	0.0975	0.3705	-0.0336	0.195	511.425	23.357	463.0269
20	0.0362	0.0301	0.037	0.134	-0.0476	0.1796	0.0908	-0.1612	0.3836	0.1527	0.0899	0.1176	-0.2089	-0.0858	0.1066	0.3042	-0.064	0.085	0.1873	-0.0384	0.4125	484.3496	37.1119	465.0264
21	0.0237	0.016	-0.0123	0.0121	-0.0257	0.0416	0.0622	-0.0943	0.0899	0.1759	-0.0007	0.0937	0.1124	-0.0152	0.0965	0.3725	-0.1275	0.0337	0.2651	-0.1232	0.226	508.5217	26.9764	485.9648
22	0.0945	-0.0904	0.0368	0.1029	-0.0711	0.0427	0.1569	-0.0586	-0.0498	-0.0082	-0.0788	-0.0709	0.0577	0.3114	0.0035	0.3105	-0.0731	0.0172	0.557	-0.0641	0.2703	492.9764	6.6902	502.1739
23	0.0682	-0.0057	-0.0086	0.0783	-0.0483	0.0608	-0.1039	-0.0267	-0.0623	0.0988	0.0674	0.085	0.09	0.2078	-0.0006	0.2082	0.056	-0.0428	0.3207	0.0186	0.3425	516.6681	6.5803	478.717
24	0.1205	0.0459	-0.0597	0.0069	-0.0219	0.0537	-0.0089	0.2314	-0.1715	-0.1252	0.0833	-0.0894	0.1489	0.1143	0.0728	0.2702	-0.0028	0.0966	0.5557	-0.1932	0.4926	503.4919	-7.3865	457.1426

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain A
2	X-RAY DIFFRACTION	2	chain B
3	X-RAY DIFFRACTION	3	chain C
4	X-RAY DIFFRACTION	4	chain D
5	X-RAY DIFFRACTION	5	chain E
6	X-RAY DIFFRACTION	6	chain F
7	X-RAY DIFFRACTION	7	chain G
8	X-RAY DIFFRACTION	8	chain H
9	X-RAY DIFFRACTION	9	chain I
10	X-RAY DIFFRACTION	10	chain J
11	X-RAY DIFFRACTION	11	chain K
12	X-RAY DIFFRACTION	12	chain L
13	X-RAY DIFFRACTION	13	chain M
14	X-RAY DIFFRACTION	14	chain N
15	X-RAY DIFFRACTION	15	chain O
16	X-RAY DIFFRACTION	16	chain P
17	X-RAY DIFFRACTION	17	chain Q
18	X-RAY DIFFRACTION	18	chain R
19	X-RAY DIFFRACTION	19	chain S
20	X-RAY DIFFRACTION	20	chain T
21	X-RAY DIFFRACTION	21	chain U
22	X-RAY DIFFRACTION	22	chain V
23	X-RAY DIFFRACTION	23	chain W
24	X-RAY DIFFRACTION	24	chain X

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