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-基本情報
登録情報 | データベース: PDB / ID: 6a22 | ||||||
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タイトル | Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T. | ||||||
要素 |
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キーワード | NUCLEAR PROTEIN/INHIBITOR / Ternary Complex / Nuclear Receptor (核内受容体) / NUCLEAR PROTEIN / NUCLEAR PROTEIN-INHIBITOR complex | ||||||
機能・相同性 | 機能・相同性情報 Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / nuclear glucocorticoid receptor binding / Peyer's patch development / T-helper cell differentiation ...Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / nuclear glucocorticoid receptor binding / Peyer's patch development / T-helper cell differentiation / positive regulation of circadian rhythm / oxysterol binding / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process / Notch binding / regulation of fat cell differentiation / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / Notch-HLH transcription pathway / Regulation of MECP2 expression and activity / regulation of glucose metabolic process / estrous cycle / lymph node development / adipose tissue development / nuclear retinoid X receptor binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / response to organonitrogen compound / 授乳 / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / xenobiotic metabolic process / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / circadian regulation of gene expression / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / DNA-binding transcription repressor activity, RNA polymerase II-specific / nuclear matrix / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / HCMV Early Events / Nuclear Receptor transcription pathway / transcription corepressor activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / response to estradiol / Interleukin-4 and Interleukin-13 signaling / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin binding / クロマチン / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / 核質 / 生体膜 / 細胞核 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.55 Å | ||||||
データ登録者 | Noguchi, M. / Nomura, A. / Doi, S. / Yamaguchi, K. / Adachi, T. | ||||||
引用 | ジャーナル: Sci Rep / 年: 2018 タイトル: Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction 著者: Noguchi, M. / Nomura, A. / Doi, S. / Yamaguchi, K. / Hirata, K. / Shiozaki, M. / Maeda, K. / Hirashima, S. / Kotoku, M. / Yamaguchi, T. / Katsuda, Y. / Crowe, P. / Tao, H. / Thacher, S. / Adachi, T. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6a22.cif.gz | 211.8 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6a22.ent.gz | 169.7 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 6a22.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/a2/6a22 ftp://data.pdbj.org/pub/pdb/validation_reports/a2/6a22 | HTTPS FTP |
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-関連構造データ
関連構造データ | 5x8xS S: 精密化の開始モデル |
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類似構造データ |
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域: Component-ID: 0 / Refine code: 0
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