Entry Database : PDB / ID : 5z1d Structure visualization Downloads & linksTitle MAP2K7 C276S mutant-inhibitor ComponentsDual specificity mitogen-activated protein kinase kinase 7 Details Keywords TRANSFERASE / protein kinaseFunction / homology Function and homology informationFunction Domain/homology Component
JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / : / positive regulation of telomere capping / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / Uptake and function of anthrax toxins / cellular response to interleukin-1 ... JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / : / positive regulation of telomere capping / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / Uptake and function of anthrax toxins / cellular response to interleukin-1 / MAP kinase activity / response to tumor necrosis factor / response to UV / stress-activated MAPK cascade / JNK cascade / positive regulation of JUN kinase activity / positive regulation of telomere maintenance via telomerase / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / molecular function activator activity / FCERI mediated MAPK activation / positive regulation of JNK cascade / response to wounding / cellular senescence / response to heat / cellular response to lipopolysaccharide / protein phosphatase binding / protein tyrosine kinase activity / Oxidative Stress Induced Senescence / positive regulation of ERK1 and ERK2 cascade / protein serine kinase activity / apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / enzyme binding / magnesium ion binding / signal transduction / ATP binding / nucleus / cytosol / cytoplasm Similarity search - Function : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily ... : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.28 Å DetailsAuthors Kinoshita, T. / London, N. CitationJournal : Cell Chem Biol / Year : 2019Title : Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.Authors: Shraga, A. / Olshvang, E. / Davidzohn, N. / Khoshkenar, P. / Germain, N. / Shurrush, K. / Carvalho, S. / Avram, L. / Albeck, S. / Unger, T. / Lefker, B. / Subramanyam, C. / Hudkins, R.L. / ... Authors : Shraga, A. / Olshvang, E. / Davidzohn, N. / Khoshkenar, P. / Germain, N. / Shurrush, K. / Carvalho, S. / Avram, L. / Albeck, S. / Unger, T. / Lefker, B. / Subramanyam, C. / Hudkins, R.L. / Mitchell, A. / Shulman, Z. / Kinoshita, T. / London, N. History Deposition Dec 26, 2017 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 2, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jul 17, 2019 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations Category : citation / citation_author ... citation / citation_author / pdbx_validate_close_contact / struct_conn Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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