登録情報 | データベース: PDB / ID: 5ywy |
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タイトル | Crystal structure of the human prostaglandin E receptor EP4 in complex with Fab and ONO-AE3-208 |
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要素 | - Heavy chain of Fab fragment
- Light chain of Fab fragment
- Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype
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キーワード | SIGNALING PROTEIN-IMMUNE SYSTEM / G-protein coupled receptor / lipid mediator / functional antibody / SIGNALING PROTEIN-IMMUNE SYSTEM complex / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
negative regulation of eosinophil extravasation / prostaglandin E receptor activity / Prostanoid ligand receptors / negative regulation of integrin activation / response to nematode / T-helper cell differentiation / regulation of stress fiber assembly / negative regulation of cytokine production / regulation of ossification / response to mechanical stimulus ...negative regulation of eosinophil extravasation / prostaglandin E receptor activity / Prostanoid ligand receptors / negative regulation of integrin activation / response to nematode / T-helper cell differentiation / regulation of stress fiber assembly / negative regulation of cytokine production / regulation of ossification / response to mechanical stimulus / JNK cascade / ERK1 and ERK2 cascade / positive regulation of cytokine production / bone development / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / negative regulation of inflammatory response / positive regulation of inflammatory response / cellular response to mechanical stimulus / cellular response to prostaglandin E stimulus / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / response to lipopolysaccharide / inflammatory response / immune response / membrane / plasma membrane類似検索 - 分子機能 Prostanoid EP4 receptor / Prostaglandin DP receptor / Prostanoid receptor / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulins / Immunoglobulin-like ...Prostanoid EP4 receptor / Prostaglandin DP receptor / Prostanoid receptor / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Chem-7UR / Prostaglandin E2 receptor EP4 subtype類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Toyoda, Y. / Morimoto, K. / Suno, R. / Horita, S. / Iwata, S. / Kobayashi, T. |
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資金援助 | 日本, 2件 組織 | 認可番号 | 国 |
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Japan Science and Technology Agency | | 日本 | Japan Agency for Medical Research and Development | | 日本 |
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引用 | ジャーナル: Nat. Chem. Biol. / 年: 2019 タイトル: Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface. 著者: Toyoda, Y. / Morimoto, K. / Suno, R. / Horita, S. / Yamashita, K. / Hirata, K. / Sekiguchi, Y. / Yasuda, S. / Shiroishi, M. / Shimizu, T. / Urushibata, Y. / Kajiwara, Y. / Inazumi, T. / ...著者: Toyoda, Y. / Morimoto, K. / Suno, R. / Horita, S. / Yamashita, K. / Hirata, K. / Sekiguchi, Y. / Yasuda, S. / Shiroishi, M. / Shimizu, T. / Urushibata, Y. / Kajiwara, Y. / Inazumi, T. / Hotta, Y. / Asada, H. / Nakane, T. / Shiimura, Y. / Nakagita, T. / Tsuge, K. / Yoshida, S. / Kuribara, T. / Hosoya, T. / Sugimoto, Y. / Nomura, N. / Sato, M. / Hirokawa, T. / Kinoshita, M. / Murata, T. / Takayama, K. / Yamamoto, M. / Narumiya, S. / Iwata, S. / Kobayashi, T. |
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履歴 | 登録 | 2017年11月30日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年12月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年12月12日 | Group: Data collection / Structure summary / カテゴリ: struct / Item: _struct.title |
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改定 1.2 | 2018年12月19日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_volume ..._citation.journal_abbrev / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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