登録情報 | データベース: PDB / ID: 5ygi |
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タイトル | Crystal structure of human FPPS in complex with an inhibitor THZ93 |
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要素 | Farnesyl pyrophosphate synthase |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / THZ93 / Complex / human FPPS / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding ...geranyl diphosphate biosynthetic process / dimethylallyltranstransferase / (2E,6E)-farnesyl diphosphate synthase / Cholesterol biosynthesis / farnesyl diphosphate biosynthetic process / dimethylallyltranstransferase activity / geranyltranstransferase activity / cholesterol biosynthetic process / Activation of gene expression by SREBF (SREBP) / RNA binding / nucleoplasm / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 Farnesyl pyrophosphate synthase-like / Polyprenyl synthases signature 1. / Polyprenyl synthases signature 2. / Polyprenyl synthetase, conserved site / Polyprenyl synthetase / Polyprenyl synthetase / Farnesyl Diphosphate Synthase / Farnesyl Diphosphate Synthase / Isoprenoid synthase domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 PHOSPHATE ION / Chem-T93 / Farnesyl pyrophosphate synthase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.177 Å |
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データ登録者 | Li, X. |
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引用 | ジャーナル: Cell / 年: 2018 タイトル: The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. 著者: Xia, Y. / Xie, Y. / Yu, Z. / Xiao, H. / Jiang, G. / Zhou, X. / Yang, Y. / Li, X. / Zhao, M. / Li, L. / Zheng, M. / Han, S. / Zong, Z. / Meng, X. / Deng, H. / Ye, H. / Fa, Y. / Wu, H. / ...著者: Xia, Y. / Xie, Y. / Yu, Z. / Xiao, H. / Jiang, G. / Zhou, X. / Yang, Y. / Li, X. / Zhao, M. / Li, L. / Zheng, M. / Han, S. / Zong, Z. / Meng, X. / Deng, H. / Ye, H. / Fa, Y. / Wu, H. / Oldfield, E. / Hu, X. / Liu, W. / Shi, Y. / Zhang, Y. |
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履歴 | 登録 | 2017年9月23日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2018年9月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年4月10日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_CSD ..._citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年3月27日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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