Entry | Database: PDB / ID: 5yef |
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Title | Crystal structure of CTCF ZFs2-8-Hs5-1aE |
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Components | - (DNA (27-MER)) x 2
- Transcriptional repressor CTCF
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Keywords | DNA BINDING PROTEIN/DNA / zinc fingers / insulators / enhancers / promoters / 3D genome / topological domains / contact loops / higher-order chromatin structure / DNA BINDING PROTEIN-DNA complex |
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Function / homology | Function and homology information
chromatin loop anchoring activity / chromatin insulator sequence binding / regulation of centromeric sister chromatid cohesion / genomic imprinting / protein localization to chromosome, centromeric region / chromatin looping / negative regulation of gene expression via chromosomal CpG island methylation / chromosome, centromeric region / condensed chromosome / epigenetic regulation of gene expression ...chromatin loop anchoring activity / chromatin insulator sequence binding / regulation of centromeric sister chromatid cohesion / genomic imprinting / protein localization to chromosome, centromeric region / chromatin looping / negative regulation of gene expression via chromosomal CpG island methylation / chromosome, centromeric region / condensed chromosome / epigenetic regulation of gene expression / male germ cell nucleus / transcription coregulator binding / chromosome segregation / DNA-binding transcription repressor activity, RNA polymerase II-specific / Activation of anterior HOX genes in hindbrain development during early embryogenesis / sequence-specific double-stranded DNA binding / sequence-specific DNA binding / transcription cis-regulatory region binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / positive regulation of gene expression / nucleolus / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / nucleusSimilarity search - Function C2H2-type zinc-finger domain / Zinc finger, C2H2 type / zinc finger / Zinc finger C2H2 type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-typeSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) synthetic construct (others) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.807 Å |
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Authors | Yin, M. / Wang, J. / Wang, M. / Li, X. / Wang, Y. |
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Funding support | China, 7items Organization | Grant number | Country |
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National Natural Science Foundation of China | 31630015 | China | National Natural Science Foundation of China | 91440201 | China | National Natural Science Foundation of China | 31571335 | China | National Natural Science Foundation of China | 31400640 | China | National Natural Science Foundation of China | 31630039 | China | National Natural Science Foundation of China | 91640118 | China | National Natural Science Foundation of China | 31470820 | China |
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Citation | Journal: Cell Res. / Year: 2017 Title: Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites Authors: Yin, M. / Wang, J. / Wang, M. / Li, X. / Zhang, M. / Wu, Q. / Wang, Y. |
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History | Deposition | Sep 17, 2017 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Nov 29, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 25, 2019 | Group: Derived calculations Category: pdbx_struct_assembly_gen / pdbx_struct_assembly_prop Item: _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.value |
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Revision 1.2 | Mar 27, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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