- PDB-5xyf: Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 5xyf
Title
Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex
Components
Adrenocortical dysplasia protein homolog
TERF1-interacting nuclear factor 2
Telomeric repeat-binding factor 2
Keywords
PROTEIN BINDING / telomere / shelterin complex
Function / homology
Function and homology information
regulation of telomere maintenance via telomere lengthening / positive regulation of single-stranded telomeric DNA binding / perinucleolar chromocenter / axonal transport of messenger ribonucleoprotein complex / negative regulation of beta-galactosidase activity / negative regulation of telomere single strand break repair / negative regulation of telomere maintenance via recombination / telomeric loop formation / telomere assembly / segmentation ...regulation of telomere maintenance via telomere lengthening / positive regulation of single-stranded telomeric DNA binding / perinucleolar chromocenter / axonal transport of messenger ribonucleoprotein complex / negative regulation of beta-galactosidase activity / negative regulation of telomere single strand break repair / negative regulation of telomere maintenance via recombination / telomeric loop formation / telomere assembly / segmentation / negative regulation of telomere maintenance via semi-conservative replication / negative regulation of exonuclease activity / urogenital system development / negative regulation of telomeric D-loop disassembly / negative regulation of protein ADP-ribosylation / negative regulation of telomere capping / protection from non-homologous end joining at telomere / establishment of protein localization to telomere / negative regulation of t-circle formation / telomerase activity / telomeric D-loop disassembly / shelterin complex / Telomere C-strand synthesis initiation / double-stranded telomeric DNA binding / regulation of telomere maintenance via telomerase / Telomere C-strand (Lagging Strand) Synthesis / positive regulation of telomere maintenance / nuclear telomere cap complex / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / anterograde axonal transport / G-rich strand telomeric DNA binding / telomere capping / telomerase holoenzyme complex / embryonic limb morphogenesis / regulation of telomere maintenance / negative regulation of telomere maintenance via telomere lengthening / protein localization to chromosome, telomeric region / telomeric DNA binding / negative regulation of cellular senescence / negative regulation of telomere maintenance via telomerase / Telomere Extension By Telomerase / telomere maintenance via telomerase / DNA polymerase binding / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / axon cytoplasm / : / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / positive regulation of telomere maintenance via telomerase / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere maintenance / positive regulation of nitric-oxide synthase activity / male germ cell nucleus / skeletal system development / intracellular protein transport / DNA Damage/Telomere Stress Induced Senescence / nuclear matrix / negative regulation of epithelial cell proliferation / cellular senescence / in utero embryonic development / chromosome, telomeric region / nuclear body / cell cycle / negative regulation of gene expression / positive regulation of gene expression / protein-containing complex binding / enzyme binding / protein homodimerization activity / nucleoplasm / nucleus Similarity search - Function