登録情報 データベース : PDB / ID : 5xpi 構造の表示 ダウンロードとリンクタイトル Structure of UHRF1 TTD in complex with NV01 要素E3 ubiquitin-protein ligase UHRF1 詳細 キーワード LIGASE / TTD domain / small molecule機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3 ubiquitin ligase activity / H3K9me3 modified histone binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / DNA damage sensor activity / hemi-methylated DNA-binding / homologous recombination / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly ... histone H3 ubiquitin ligase activity / H3K9me3 modified histone binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / DNA damage sensor activity / hemi-methylated DNA-binding / homologous recombination / regulation of epithelial cell proliferation / methyl-CpG binding / negative regulation of gene expression via chromosomal CpG island methylation / mitotic spindle assembly / protein autoubiquitination / cis-regulatory region sequence-specific DNA binding / heterochromatin / heterochromatin formation / epigenetic regulation of gene expression / methylated histone binding / positive regulation of protein metabolic process / DNA methylation / Chromatin modifications during the maternal to zygotic transition (MZT) / replication fork / double-strand break repair via homologous recombination / euchromatin / RING-type E3 ubiquitin transferase / nuclear matrix / spindle / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / histone binding / ubiquitin-dependent protein catabolic process / nucleic acid binding / protein ubiquitination / DNA damage response / chromatin / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 : / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / SH3 type barrels. - #30 ... : / UHRF1, tandem tudor domain / UHRF1/2-like / Tandem tudor domain within UHRF1 / SRA-YDG / SRA-YDG superfamily / SAD/SRA domain / YDG domain profile. / SET and RING finger associated domain. Domain of unknown function in SET domain containing proteins and in Deinococcus radiodurans DRA1533. / SH3 type barrels. - #30 / PUA-like superfamily / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / PHD-finger / Ring finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, FYVE/PHD-type / SH3 type barrels. / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Zinc finger, RING/FYVE/PHD-type / Ubiquitin-like domain superfamily / Roll / Mainly Beta 類似検索 - ドメイン・相同性 Chem-8C3 / E3 ubiquitin-protein ligase UHRF1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Luo, X. / Zhao, K. 引用ジャーナル : SLAS Discov / 年 : 2018タイトル : Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain著者: Senisterra, G. / Zhu, H.Y. / Luo, X. / Zhang, H. / Xun, G. / Lu, C. / Xiao, W. / Hajian, T. / Loppnau, P. / Chau, I. / Li, F. / Allali-Hassani, A. / Atadja, P. / Oyang, C. / Li, E. / Brown, P. ... 著者 : Senisterra, G. / Zhu, H.Y. / Luo, X. / Zhang, H. / Xun, G. / Lu, C. / Xiao, W. / Hajian, T. / Loppnau, P. / Chau, I. / Li, F. / Allali-Hassani, A. / Atadja, P. / Oyang, C. / Li, E. / Brown, P.J. / Arrowsmith, C.H. / Zhao, K. / Yu, Z. / Vedadi, M. 履歴 登録 2017年6月2日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2018年4月25日 Provider : repository / タイプ : Initial release改定 1.1 2018年7月18日 Group : Data collection / カテゴリ : diffrn_source / Item : _diffrn_source.source改定 1.2 2018年10月3日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2023年11月22日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item : _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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