登録情報 データベース : PDB / ID : 5x6g 構造の表示 ダウンロードとリンクタイトル Crystal Structure of SMAD5-MH1/palindromic SBE DNA complex 要素DNA (5'-D(P*AP*TP*CP*AP*GP*TP*CP*TP*AP*GP*AP*CP*AP*TP*A)-3')DNA (5'-D(P*GP*TP*AP*TP*GP*TP*CP*TP*AP*GP*AP*CP*TP*GP*A)-3')Mothers against decapentaplegic homolog 5 詳細キーワード METAL BINDING PROTEIN/DNA / Smad5 / MH1 domain / protein-DNA complex / SBE / METAL BINDING PROTEIN-DNA complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of Fas signaling pathway / Mullerian duct regression / Signaling by BMP / osteoblast fate commitment / heteromeric SMAD protein complex / DEAD/H-box RNA helicase binding / embryonic pattern specification / SMAD protein signal transduction / I-SMAD binding / cartilage development ... negative regulation of Fas signaling pathway / Mullerian duct regression / Signaling by BMP / osteoblast fate commitment / heteromeric SMAD protein complex / DEAD/H-box RNA helicase binding / embryonic pattern specification / SMAD protein signal transduction / I-SMAD binding / cartilage development / ureteric bud development / germ cell development / cellular response to organic cyclic compound / anatomical structure morphogenesis / BMP signaling pathway / positive regulation of osteoblast differentiation / cardiac muscle contraction / erythrocyte differentiation / transforming growth factor beta receptor signaling pathway / RNA polymerase II transcription regulatory region sequence-specific DNA binding / bone development / DNA-binding transcription repressor activity, RNA polymerase II-specific / angiogenesis / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / ubiquitin protein ligase binding / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / nucleoplasm / nucleus / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins ... Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / SMAD/FHA domain superfamily / Alpha-Beta Complex / Alpha Beta 類似検索 - ドメイン・相同性 DNA / DNA (> 10) / Mothers against decapentaplegic homolog 5 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.05 Å 詳細データ登録者 Chai, N. / Wang, J. / Wang, Z.X. / Wu, J.W. 資金援助 中国, 2件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China 31130062 中国 China National Basic Research Program 2013CB530600 中国
引用ジャーナル : Nucleic Acids Res. / 年 : 2015タイトル : Structural basis for the Smad5 MH1 domain to recognize different DNA sequences.著者 : Chai, N. / Li, W.X. / Wang, J. / Wang, Z.X. / Yang, S.M. / Wu, J.W. 履歴 登録 2017年2月21日 登録サイト : PDBJ / 処理サイト : PDBJ置き換え 2017年3月15日 ID : 4ZKG 改定 1.0 2017年3月15日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月22日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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