Entry | Database: PDB / ID: 5wqj |
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Title | Crystal structure of 3-Mercaptopyruvate Sulfurtransferase(3MST) in complex with compound1 |
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Components | Sulfurtransferase |
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Keywords | TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR complex |
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Function / homology | Function and homology information
3-mercaptopyruvate sulfurtransferase / Degradation of cysteine and homocysteine / 3-mercaptopyruvate sulfurtransferase activity / thiosulfate sulfurtransferase activity / hydrogen sulfide biosynthetic process / transsulfuration / spinal cord development / liver development / kidney development / mitochondrial inner membrane ...3-mercaptopyruvate sulfurtransferase / Degradation of cysteine and homocysteine / 3-mercaptopyruvate sulfurtransferase activity / thiosulfate sulfurtransferase activity / hydrogen sulfide biosynthetic process / transsulfuration / spinal cord development / liver development / kidney development / mitochondrial inner membrane / neuron projection / synapse / mitochondrion / identical protein binding / cytoplasm / cytosolSimilarity search - Function Sulfurtransferase TST/MPST-like / Rhodanese signature 1. / Rhodanese C-terminal signature. / Thiosulphate sulfurtransferase, conserved site / Rhodanese-like domain / Oxidized Rhodanese; domain 1 / Rhodanese Homology Domain / Rhodanese-like domain / Rhodanese domain profile. / Rhodanese-like domain superfamily ...Sulfurtransferase TST/MPST-like / Rhodanese signature 1. / Rhodanese C-terminal signature. / Thiosulphate sulfurtransferase, conserved site / Rhodanese-like domain / Oxidized Rhodanese; domain 1 / Rhodanese Homology Domain / Rhodanese-like domain / Rhodanese domain profile. / Rhodanese-like domain superfamily / Rhodanese-like domain / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.2 Å |
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Authors | Suwanai, Y. / Toma-Fukai, S. / Shimizu, T. |
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Citation | Journal: Sci Rep / Year: 2017 Title: Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide Authors: Hanaoka, K. / Sasakura, K. / Suwanai, Y. / Toma-Fukai, S. / Shimamoto, K. / Takano, Y. / Shibuya, N. / Terai, T. / Komatsu, T. / Ueno, T. / Ogasawara, Y. / Tsuchiya, Y. / Watanabe, Y. / ...Authors: Hanaoka, K. / Sasakura, K. / Suwanai, Y. / Toma-Fukai, S. / Shimamoto, K. / Takano, Y. / Shibuya, N. / Terai, T. / Komatsu, T. / Ueno, T. / Ogasawara, Y. / Tsuchiya, Y. / Watanabe, Y. / Kimura, H. / Wang, C. / Uchiyama, M. / Kojima, H. / Okabe, T. / Urano, Y. / Shimizu, T. / Nagano, T. |
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History | Deposition | Nov 27, 2016 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Sep 6, 2017 | Provider: repository / Type: Initial release |
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