Entry Database : PDB / ID : 5w7j Structure visualization Downloads & linksTitle X-ray structure of the E89A variant of ankyrin repeat domain of DHHC17 in complex with Snap25b peptide ComponentsPalmitoyltransferase ZDHHC17 Snap25b-111-120 DetailsKeywords PROTEIN BINDING / Palmitoyltransferases / DHHC17 / Snap25 / Ankyrin repeat domainFunction / homology Function and homology informationFunction Domain/homology Component
regulation of neurotrophin TRK receptor signaling pathway / protein-cysteine S-myristoyltransferase activity / protein-cysteine S-stearoyltransferase activity / Toxicity of botulinum toxin type C (botC) / protein S-acyltransferase / protein palmitoylation / protein-cysteine S-palmitoyltransferase activity / neurotransmitter uptake / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane ... regulation of neurotrophin TRK receptor signaling pathway / protein-cysteine S-myristoyltransferase activity / protein-cysteine S-stearoyltransferase activity / Toxicity of botulinum toxin type C (botC) / protein S-acyltransferase / protein palmitoylation / protein-cysteine S-palmitoyltransferase activity / neurotransmitter uptake / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / extrinsic component of presynaptic membrane / Acetylcholine Neurotransmitter Release Cycle / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / Toxicity of botulinum toxin type A (botA) / synaptic vesicle fusion to presynaptic active zone membrane / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / presynaptic dense core vesicle exocytosis / palmitoyltransferase activity / ribbon synapse / synaptic vesicle docking / Dopamine Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / regulation of programmed cell death / SNARE complex / SNAP receptor activity / Glutamate Neurotransmitter Release Cycle / Golgi-associated vesicle membrane / neurotransmitter receptor internalization / Sensory processing of sound by inner hair cells of the cochlea / syntaxin-1 binding / SNARE complex assembly / synaptic vesicle priming / lipoprotein transport / endosomal transport / regulation of synapse assembly / Other interleukin signaling / myosin binding / regulation of neuron projection development / exocytosis / voltage-gated potassium channel activity / synaptic vesicle exocytosis / associative learning / regulation of insulin secretion / tertiary granule membrane / long-term memory / axonal growth cone / specific granule membrane / presynaptic active zone membrane / voltage-gated potassium channel complex / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / photoreceptor inner segment / regulation of ERK1 and ERK2 cascade / axonogenesis / filopodium / locomotory behavior / cell projection / Regulation of insulin secretion / long-term synaptic potentiation / trans-Golgi network / positive regulation of insulin secretion / calcium-dependent protein binding / actin cytoskeleton / synaptic vesicle / lamellipodium / presynaptic membrane / cell cortex / growth cone / chemical synaptic transmission / positive regulation of canonical NF-kappaB signal transduction / transmembrane transporter binding / postsynapse / cytoskeleton / endosome / neuron projection / protein domain specific binding / Golgi membrane / intracellular membrane-bounded organelle / signaling receptor binding / neuronal cell body / lipid binding / glutamatergic synapse / Neutrophil degranulation / perinuclear region of cytoplasm / Golgi apparatus / identical protein binding / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function Palmitoyltransferase, DHHC domain / DHHC palmitoyltransferase / DHHC domain profile. / Synaptosomal-associated protein 25 / SNAP-25 domain / SNAP-25 family / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Ankyrin repeat-containing domain ... Palmitoyltransferase, DHHC domain / DHHC palmitoyltransferase / DHHC domain profile. / Synaptosomal-associated protein 25 / SNAP-25 domain / SNAP-25 family / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Ankyrin repeat-containing domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.202 Å DetailsAuthors Verardi, R. / Kim, J.-S. / Ghirlando, R. / Banerjee, A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) 1ZIAHD008928 United States
CitationJournal : Structure / Year : 2017Title : Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.Authors : Verardi, R. / Kim, J.S. / Ghirlando, R. / Banerjee, A. History Deposition Jun 20, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 9, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 16, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name Revision 1.2 Sep 20, 2017 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 Dec 11, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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