登録情報 | データベース: PDB / ID: 5w0p |
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タイトル | Crystal structure of rhodopsin bound to visual arrestin determined by X-ray free electron laser |
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要素 | (Endolysin,Rhodopsin,S-arrestin) x 2 |
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キーワード | SIGNALING PROTEIN / rhodopsin / GPCR / arrestin / GRK / phosphorylation codes / membrane proteins |
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機能・相同性 | 機能・相同性情報
Opsins / Inactivation, recovery and regulation of the phototransduction cascade / opsin binding / rod bipolar cell differentiation / sperm head plasma membrane / absorption of visible light / G protein-coupled opsin signaling pathway / photoreceptor inner segment membrane / podosome assembly / VxPx cargo-targeting to cilium ...Opsins / Inactivation, recovery and regulation of the phototransduction cascade / opsin binding / rod bipolar cell differentiation / sperm head plasma membrane / absorption of visible light / G protein-coupled opsin signaling pathway / photoreceptor inner segment membrane / podosome assembly / VxPx cargo-targeting to cilium / 11-cis retinal binding / G protein-coupled photoreceptor activity / rod photoreceptor outer segment / cellular response to light stimulus / Golgi-associated vesicle membrane / thermotaxis / response to light intensity / phototransduction, visible light / detection of temperature stimulus involved in thermoception / photoreceptor cell maintenance / G protein-coupled receptor internalization / ciliary membrane / photoreceptor outer segment membrane / spectrin binding / The canonical retinoid cycle in rods (twilight vision) / phototransduction / photoreceptor outer segment / viral release from host cell by cytolysis / sperm midpiece / visual perception / photoreceptor inner segment / peptidoglycan catabolic process / G protein-coupled receptor binding / G protein-coupled receptor activity / phosphoprotein binding / Activation of the phototransduction cascade / photoreceptor disc membrane / microtubule cytoskeleton organization / Inactivation, recovery and regulation of the phototransduction cascade / cell-cell junction / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / gene expression / G alpha (i) signalling events / host cell cytoplasm / defense response to bacterium / G protein-coupled receptor signaling pathway / Golgi membrane / Golgi apparatus / signal transduction / membrane / metal ion binding / plasma membrane類似検索 - 分子機能 Rhodopsin, N-terminal / Amino terminal of the G-protein receptor rhodopsin / Rhodopsin / Arrestin, conserved site / Arrestins signature. / Arrestin / Opsin / Arrestin, N-terminal / Visual pigments (opsins) retinal binding site / Visual pigments (opsins) retinal binding site. ...Rhodopsin, N-terminal / Amino terminal of the G-protein receptor rhodopsin / Rhodopsin / Arrestin, conserved site / Arrestins signature. / Arrestin / Opsin / Arrestin, N-terminal / Visual pigments (opsins) retinal binding site / Visual pigments (opsins) retinal binding site. / : / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin-like, C-terminal / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily / Immunoglobulin E-set類似検索 - ドメイン・相同性 Endolysin / Endolysin / Rhodopsin / S-arrestin類似検索 - 構成要素 |
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生物種 | Enterobacteria phage RB55 (ファージ)
Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / 自由電子レーザー / 分子置換 / 解像度: 3.013 Å |
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データ登録者 | Zhou, X.E. / He, Y. / de Waal, P.W. / Gao, X. / Kang, Y. / Van Eps, N. / Yin, Y. / Pal, K. / Goswami, D. / White, T.A. ...Zhou, X.E. / He, Y. / de Waal, P.W. / Gao, X. / Kang, Y. / Van Eps, N. / Yin, Y. / Pal, K. / Goswami, D. / White, T.A. / Barty, A. / Latorraca, N.R. / Chapman, H.N. / Hubbell, W.L. / Dror, R.O. / Stevens, R.C. / Cherezov, V. / Gurevich, V.V. / Griffin, P.R. / Ernst, O.P. / Melcher, K. / Xu, H.E. |
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資金援助 | 米国, 中国, カナダ, 12件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | DK071662 | 米国 | Ministry of Science and Technology (MoST, China) | 2012ZX09301001 | 中国 | Ministry of Science and Technology (MoST, China) | 2012CB910403 | 中国 | Ministry of Science and Technology (MoST, China) | 2013CB910600 | 中国 | Ministry of Science and Technology (MoST, China) | XDB08020303 | 中国 | Ministry of Science and Technology (MoST, China) | 2013ZX09507001 | 中国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM108635 | 米国 | National Institutes of Health/National Eye Institute (NIH/NEI) | RO1 EY011500 | 米国 | American Asthma Foundation | | 米国 | Jay and Betty Van Andel Foundation | | 米国 | Canada Excellence Research Chairs program | | カナダ | Anne and Max Tanenbaum Chair in Neuroscience | | カナダ |
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引用 | ジャーナル: Cell / 年: 2017 タイトル: Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. 著者: Zhou, X.E. / He, Y. / de Waal, P.W. / Gao, X. / Kang, Y. / Van Eps, N. / Yin, Y. / Pal, K. / Goswami, D. / White, T.A. / Barty, A. / Latorraca, N.R. / Chapman, H.N. / Hubbell, W.L. / Dror, R. ...著者: Zhou, X.E. / He, Y. / de Waal, P.W. / Gao, X. / Kang, Y. / Van Eps, N. / Yin, Y. / Pal, K. / Goswami, D. / White, T.A. / Barty, A. / Latorraca, N.R. / Chapman, H.N. / Hubbell, W.L. / Dror, R.O. / Stevens, R.C. / Cherezov, V. / Gurevich, V.V. / Griffin, P.R. / Ernst, O.P. / Melcher, K. / Xu, H.E. |
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履歴 | 登録 | 2017年5月31日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年8月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月27日 | Group: Author supporting evidence / Data collection / カテゴリ: diffrn_source / pdbx_audit_support Item: _diffrn_source.pdbx_synchrotron_beamline / _diffrn_source.pdbx_synchrotron_site / _pdbx_audit_support.funding_organization |
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改定 1.2 | 2018年11月21日 | Group: Data collection カテゴリ: pdbx_serial_crystallography_data_reduction / pdbx_serial_crystallography_measurement ...pdbx_serial_crystallography_data_reduction / pdbx_serial_crystallography_measurement / pdbx_serial_crystallography_sample_delivery / pdbx_serial_crystallography_sample_delivery_injection |
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改定 1.3 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 2.0 | 2020年7月29日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.auth_asym_id / _atom_site.auth_seq_id ..._atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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