登録情報 | データベース: PDB / ID: 5veb |
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タイトル | Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 |
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要素 | - (anti-CDH6 Fab heavy ...) x 2
- Cadherin-6
- anti-CDH6 Fab light chain
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キーワード | IMMUNE SYSTEM / antibody / cell adhesion / antibody-drug conjugate / cancer |
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機能・相同性 | 機能・相同性情報
IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / multicellular organism development / IgE immunoglobulin complex / cell-cell adhesion via plasma-membrane adhesion molecules / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / CD22 mediated BCR regulation / catenin complex / Adherens junctions interactions ...IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / multicellular organism development / IgE immunoglobulin complex / cell-cell adhesion via plasma-membrane adhesion molecules / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / CD22 mediated BCR regulation / catenin complex / Adherens junctions interactions / IgG immunoglobulin complex / cell-cell junction assembly / adherens junction organization / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement / homophilic cell adhesion via plasma membrane adhesion molecules / FCGR activation / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / immunoglobulin complex, circulating / immunoglobulin receptor binding / Notch signaling pathway / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / complement activation, classical pathway / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of Complement cascade / antigen binding / Cell surface interactions at the vascular wall / FCERI mediated MAPK activation / adherens junction / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / cell morphogenesis / Regulation of actin dynamics for phagocytic cup formation / FCERI mediated NF-kB activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / cell junction / antibacterial humoral response / adaptive immune response / Potential therapeutics for SARS / membrane => GO:0016020 / blood microparticle / cell adhesion / cadherin binding / immune response / calcium ion binding / extracellular space / extracellular exosome / extracellular region / plasma membrane類似検索 - 分子機能 Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like ...Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like / Cadherin-like superfamily / : / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulin subtype / Immunoglobulin / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 2-acetamido-2-deoxy-alpha-D-galactopyranose / Immunoglobulin kappa constant / Cadherin-6 / IgG H chain類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.34 Å |
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データ登録者 | Zhu, X. / Bialucha, C.U. / London, A. / Clark, K. / Hu, T. |
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引用 | ジャーナル: Cancer Discov / 年: 2017 タイトル: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. 著者: Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. / Lee, D. / Ostrom, L. / Hu, T. / Bilic, S. / Rajlic, I.L. / ...著者: Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. / Lee, D. / Ostrom, L. / Hu, T. / Bilic, S. / Rajlic, I.L. / Capka, V. / Jiang, W. / Wagner, J.P. / Elliott, G. / Veloso, A. / Piel, J.C. / Flaherty, M.M. / Mansfield, K.G. / Meseck, E.K. / Rubic-Schneider, T. / London, A.S. / Tschantz, W.R. / Kurz, M. / Nguyen, D. / Bourret, A. / Meyer, M.J. / Faris, J.E. / Janatpour, M.J. / Chan, V.W. / Yoder, N.C. / Catcott, K.C. / McShea, M.A. / Sun, X. / Gao, H. / Williams, J. / Hofmann, F. / Engelman, J.A. / Ettenberg, S.A. / Sellers, W.R. / Lees, E. |
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履歴 | 登録 | 2017年4月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年6月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年9月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_validate_close_contact / struct_conn / struct_site / struct_site_gen Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_validate_close_contact.auth_atom_id_2 / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 3.0 | 2024年4月24日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Polymer sequence / Source and taxonomy / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / entity_name_com / entity_poly / entity_poly_seq / entity_src_gen / entity_src_nat / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_poly_seq_scheme / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / struct_asym / struct_conn / struct_ref / struct_ref_seq Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.group_PDB / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.label_seq_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.pdbx_synonyms / _chem_comp.type / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.src_method / _entity.type / _entity_name_com.entity_id / _pdbx_poly_seq_scheme.auth_mon_id / _pdbx_poly_seq_scheme.entity_id / _pdbx_poly_seq_scheme.mon_id / _pdbx_poly_seq_scheme.pdb_mon_id / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.value / _struct_ref_seq.ref_id |
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