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| Title | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. |
|---|---|
| Journal, issue, pages | Cancer Discov, Vol. 7, Page 1030-1045, Year 2017 |
| Publish date | Apr 4, 2017 (structure data deposition date) |
 Authors | Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. ...Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. / Lee, D. / Ostrom, L. / Hu, T. / Bilic, S. / Rajlic, I.L. / Capka, V. / Jiang, W. / Wagner, J.P. / Elliott, G. / Veloso, A. / Piel, J.C. / Flaherty, M.M. / Mansfield, K.G. / Meseck, E.K. / Rubic-Schneider, T. / London, A.S. / Tschantz, W.R. / Kurz, M. / Nguyen, D. / Bourret, A. / Meyer, M.J. / Faris, J.E. / Janatpour, M.J. / Chan, V.W. / Yoder, N.C. / Catcott, K.C. / McShea, M.A. / Sun, X. / Gao, H. / Williams, J. / Hofmann, F. / Engelman, J.A. / Ettenberg, S.A. / Sellers, W.R. / Lees, E. |
 External links | Cancer Discov / PubMed:28526733 |
| Methods | X-ray diffraction |
| Resolution | 2.34 Å |
| Structure data |  PDB-5veb: |
| Chemicals |  ChemComp-A2G:  ChemComp-HOH: |
| Source |
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 Keywords | IMMUNE SYSTEM / antibody / cell adhesion / antibody-drug conjugate / cancer |
homo sapiens (human)