Entry Database : PDB / ID : 5veb Structure visualization Downloads & linksTitle Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 Components(anti-CDH6 Fab heavy ...) x 2 Cadherin-6 anti-CDH6 Fab light chain DetailsKeywords IMMUNE SYSTEM / antibody / cell adhesion / antibody-drug conjugate / cancerFunction / homology Function and homology informationFunction Domain/homology Component
IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / multicellular organism development / IgE immunoglobulin complex / cell-cell adhesion via plasma-membrane adhesion molecules / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / CD22 mediated BCR regulation / catenin complex / Adherens junctions interactions ... IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / multicellular organism development / IgE immunoglobulin complex / cell-cell adhesion via plasma-membrane adhesion molecules / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / CD22 mediated BCR regulation / catenin complex / Adherens junctions interactions / IgG immunoglobulin complex / cell-cell junction assembly / adherens junction organization / Fc epsilon receptor (FCERI) signaling / Classical antibody-mediated complement activation / Initial triggering of complement / homophilic cell adhesion via plasma membrane adhesion molecules / FCGR activation / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / immunoglobulin complex, circulating / immunoglobulin receptor binding / Notch signaling pathway / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / complement activation, classical pathway / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / Regulation of Complement cascade / antigen binding / Cell surface interactions at the vascular wall / FCERI mediated MAPK activation / adherens junction / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / cell morphogenesis / Regulation of actin dynamics for phagocytic cup formation / FCERI mediated NF-kB activation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / cell junction / antibacterial humoral response / adaptive immune response / Potential therapeutics for SARS / membrane => GO:0016020 / blood microparticle / cell adhesion / cadherin binding / immune response / calcium ion binding / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like ... Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like / Cadherin-like superfamily / : / Immunoglobulin V-Type / Immunoglobulin V-set domain / Immunoglobulin V-set domain / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulin subtype / Immunoglobulin / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.34 Å DetailsAuthors Zhu, X. / Bialucha, C.U. / London, A. / Clark, K. / Hu, T. CitationJournal : Cancer Discov / Year : 2017Title : Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.Authors: Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. / Lee, D. / Ostrom, L. / Hu, T. / Bilic, S. / Rajlic, I.L. / ... Authors : Bialucha, C.U. / Collins, S.D. / Li, X. / Saxena, P. / Zhang, X. / Durr, C. / Lafont, B. / Prieur, P. / Shim, Y. / Mosher, R. / Lee, D. / Ostrom, L. / Hu, T. / Bilic, S. / Rajlic, I.L. / Capka, V. / Jiang, W. / Wagner, J.P. / Elliott, G. / Veloso, A. / Piel, J.C. / Flaherty, M.M. / Mansfield, K.G. / Meseck, E.K. / Rubic-Schneider, T. / London, A.S. / Tschantz, W.R. / Kurz, M. / Nguyen, D. / Bourret, A. / Meyer, M.J. / Faris, J.E. / Janatpour, M.J. / Chan, V.W. / Yoder, N.C. / Catcott, K.C. / McShea, M.A. / Sun, X. / Gao, H. / Williams, J. / Hofmann, F. / Engelman, J.A. / Ettenberg, S.A. / Sellers, W.R. / Lees, E. History Deposition Apr 4, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 7, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Sep 13, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name Revision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_validate_close_contact / struct_conn / struct_site / struct_site_gen Item : _atom_site.auth_atom_id / _atom_site.label_atom_id ... _atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_validate_close_contact.auth_atom_id_2 / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 3.0 Apr 24, 2024 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Polymer sequence / Source and taxonomy / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / entity_name_com / entity_poly / entity_poly_seq / entity_src_gen / entity_src_nat / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_poly_seq_scheme / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / struct_asym / struct_conn / struct_ref / struct_ref_seq Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.group_PDB / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.label_seq_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.pdbx_synonyms / _chem_comp.type / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.src_method / _entity.type / _entity_name_com.entity_id / _pdbx_poly_seq_scheme.auth_mon_id / _pdbx_poly_seq_scheme.entity_id / _pdbx_poly_seq_scheme.mon_id / _pdbx_poly_seq_scheme.pdb_mon_id / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.value / _struct_ref_seq.ref_id
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