- PDB-5v6y: Crystal structure of the human CLR:RAMP1 extracellular domain het... -
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Basic information
Entry
Database: PDB / ID: 5v6y
Title
Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant
Components
ADM
Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor
Keywords
TRANSPORT PROTEIN / MEMBRANE PROTEIN / class B G protein-coupled receptor / GPCR / calcitonin family peptide / TRANSPORT PROTEIN - MEMBRANE PROTEIN complex
Function / homology
Function and homology information
adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / calcitonin gene-related peptide binding / vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / positive regulation of protein glycosylation / cellular response to sucrose stimulus / adrenomedullin receptor activity ...adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / calcitonin gene-related peptide binding / vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / positive regulation of protein glycosylation / cellular response to sucrose stimulus / adrenomedullin receptor activity / adrenomedullin receptor complex / neuron projection regeneration / adrenomedullin receptor signaling pathway / amylin receptor activity / calcitonin receptor activity / spongiotrophoblast layer development / vascular associated smooth muscle cell proliferation / calcitonin gene-related peptide receptor activity / amylin receptor signaling pathway / Calcitonin-like ligand receptors / branching involved in labyrinthine layer morphogenesis / positive regulation of vasculogenesis / regulation of systemic arterial blood pressure / regulation of the force of heart contraction / regulation of G protein-coupled receptor signaling pathway / regulation of urine volume / G protein-coupled receptor internalization / negative regulation of vascular permeability / negative regulation of vasoconstriction / positive regulation of heart rate / response to starvation / odontogenesis of dentin-containing tooth / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / androgen metabolic process / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / developmental growth / maltodextrin transmembrane transport / vasculogenesis / animal organ regeneration / coreceptor activity / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / response to glucocorticoid / cellular response to hormone stimulus / positive regulation of vascular associated smooth muscle cell proliferation / cAMP-mediated signaling / neural tube closure / protein localization to plasma membrane / G protein-coupled receptor activity / female pregnancy / intracellular protein transport / response to insulin / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / receptor internalization / positive regulation of angiogenesis / calcium ion transport / protein transport / heart development / positive regulation of cytosolic calcium ion concentration / outer membrane-bounded periplasmic space / G alpha (s) signalling events / angiogenesis / cell population proliferation / response to lipopolysaccharide / cell surface receptor signaling pathway / lysosome / receptor complex / response to hypoxia / endosome / inflammatory response / positive regulation of apoptotic process / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / signaling receptor binding / positive regulation of cell population proliferation / cell surface / endoplasmic reticulum / signal transduction / extracellular space / extracellular region / plasma membrane / cytoplasm Similarity search - Function
Pro-adrenomedullin / GPCR, family 2, calcitonin gene-related peptide, type 1 receptor / Receptor activity modifying protein / RAMP domain superfamily / Receptor activity modifying family / GPCR, family 2, calcitonin receptor family / Calcitonin/adrenomedullin / Calcitonin / CGRP / IAPP family / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain ...Pro-adrenomedullin / GPCR, family 2, calcitonin gene-related peptide, type 1 receptor / Receptor activity modifying protein / RAMP domain superfamily / Receptor activity modifying family / GPCR, family 2, calcitonin receptor family / Calcitonin/adrenomedullin / Calcitonin / CGRP / IAPP family / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein Similarity search - Domain/homology
alpha-maltose / Receptor activity-modifying protein 1 / Maltose/maltodextrin-binding periplasmic protein / Pro-adrenomedullin / Calcitonin gene-related peptide type 1 receptor Similarity search - Component
Biological species
Escherichia coli O157:H7 (bacteria) Homo sapiens (human)