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Yorodumi- PDB-5v6y: Crystal structure of the human CLR:RAMP1 extracellular domain het... -
+Open data
-Basic information
Entry | Database: PDB / ID: 5v6y | ||||||||||||
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Title | Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant | ||||||||||||
Components |
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Keywords | TRANSPORT PROTEIN / MEMBRANE PROTEIN / class B G protein-coupled receptor / GPCR / calcitonin family peptide / TRANSPORT PROTEIN - MEMBRANE PROTEIN complex | ||||||||||||
Function / homology | Function and homology information adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / calcitonin gene-related peptide binding / vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / positive regulation of protein glycosylation / cellular response to sucrose stimulus / adrenomedullin receptor activity ...adrenomedullin receptor binding / positive regulation of progesterone biosynthetic process / calcitonin gene-related peptide binding / vascular associated smooth muscle cell development / CGRP receptor complex / calcitonin gene-related peptide receptor signaling pathway / adrenomedullin binding / positive regulation of protein glycosylation / cellular response to sucrose stimulus / adrenomedullin receptor activity / adrenomedullin receptor complex / neuron projection regeneration / adrenomedullin receptor signaling pathway / amylin receptor activity / calcitonin receptor activity / spongiotrophoblast layer development / vascular associated smooth muscle cell proliferation / calcitonin gene-related peptide receptor activity / amylin receptor signaling pathway / Calcitonin-like ligand receptors / branching involved in labyrinthine layer morphogenesis / positive regulation of vasculogenesis / regulation of systemic arterial blood pressure / regulation of the force of heart contraction / regulation of G protein-coupled receptor signaling pathway / regulation of urine volume / G protein-coupled receptor internalization / negative regulation of vascular permeability / negative regulation of vasoconstriction / positive regulation of heart rate / response to starvation / odontogenesis of dentin-containing tooth / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / androgen metabolic process / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / developmental growth / maltodextrin transmembrane transport / vasculogenesis / animal organ regeneration / coreceptor activity / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / response to glucocorticoid / cellular response to hormone stimulus / positive regulation of vascular associated smooth muscle cell proliferation / cAMP-mediated signaling / neural tube closure / protein localization to plasma membrane / female pregnancy / G protein-coupled receptor activity / intracellular protein transport / response to insulin / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / receptor internalization / positive regulation of angiogenesis / calcium ion transport / protein transport / heart development / outer membrane-bounded periplasmic space / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / angiogenesis / receptor complex / cell population proliferation / response to lipopolysaccharide / endosome / cell surface receptor signaling pathway / lysosome / response to hypoxia / inflammatory response / positive regulation of apoptotic process / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / signaling receptor binding / positive regulation of cell population proliferation / cell surface / signal transduction / endoplasmic reticulum / extracellular space / extracellular region / plasma membrane / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Escherichia coli O157:H7 (bacteria) Homo sapiens (human) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å | ||||||||||||
Authors | Pioszak, A. / Booe, J. | ||||||||||||
Funding support | United States, 1items
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Citation | Journal: Mol. Pharmacol. / Year: 2018 Title: Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists. Authors: Booe, J.M. / Warner, M.L. / Roehrkasse, A.M. / Hay, D.L. / Pioszak, A.A. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5v6y.cif.gz | 920 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5v6y.ent.gz | 776.7 KB | Display | PDB format |
PDBx/mmJSON format | 5v6y.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5v6y_validation.pdf.gz | 1.8 MB | Display | wwPDB validaton report |
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Full document | 5v6y_full_validation.pdf.gz | 1.8 MB | Display | |
Data in XML | 5v6y_validation.xml.gz | 72.5 KB | Display | |
Data in CIF | 5v6y_validation.cif.gz | 97.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/v6/5v6y ftp://data.pdbj.org/pub/pdb/validation_reports/v6/5v6y | HTTPS FTP |
-Related structure data
Related structure data | 4rwgS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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