登録情報 | データベース: PDB / ID: 5v5p |
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タイトル | Structure of NLS2R of influenza A virus nucleoprotein bound to importin alpha |
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要素 | - Importin subunit alpha-1
- Nucleoprotein
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キーワード | VIRAL PROTEIN / Nuclear Import / NLS |
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機能・相同性 | 機能・相同性情報
Sensing of DNA Double Strand Breaks / entry of viral genome into host nucleus through nuclear pore complex via importin / positive regulation of viral life cycle / NLS-dependent protein nuclear import complex / postsynapse to nucleus signaling pathway / nuclear import signal receptor activity / nuclear localization sequence binding / helical viral capsid / NLS-bearing protein import into nucleus / cytoplasmic stress granule ...Sensing of DNA Double Strand Breaks / entry of viral genome into host nucleus through nuclear pore complex via importin / positive regulation of viral life cycle / NLS-dependent protein nuclear import complex / postsynapse to nucleus signaling pathway / nuclear import signal receptor activity / nuclear localization sequence binding / helical viral capsid / NLS-bearing protein import into nucleus / cytoplasmic stress granule / viral penetration into host nucleus / protein import into nucleus / host cell / viral nucleocapsid / DNA-binding transcription factor binding / postsynaptic density / glutamatergic synapse / host cell nucleus / structural molecule activity / RNA binding / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 Influenza virus nucleoprotein (NP) / Influenza virus nucleoprotein / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain / IBB domain profile. / Armadillo/plakoglobin ARM repeat profile. ...Influenza virus nucleoprotein (NP) / Influenza virus nucleoprotein / Importin subunit alpha / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain superfamily / Importin beta binding domain / Atypical Arm repeat / Importin-alpha, importin-beta-binding domain / IBB domain profile. / Armadillo/plakoglobin ARM repeat profile. / Armadillo/beta-catenin-like repeat / Armadillo/beta-catenin-like repeats / Armadillo / Leucine-rich Repeat Variant / Leucine-rich Repeat Variant / Armadillo-like helical / Alpha Horseshoe / Armadillo-type fold / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
![](img/tx_virus.gif) Influenza A virus (A型インフルエンザウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.15 Å |
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データ登録者 | Sankhala, R.S. / Lokareddy, R.K. / Cingolani, G. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM100888 | 米国 |
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引用 | ジャーナル: Sci Rep / 年: 2017 タイトル: Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin alpha isoforms. 著者: Wu, W. / Sankhala, R.S. / Florio, T.J. / Zhou, L. / Nguyen, N.L.T. / Lokareddy, R.K. / Cingolani, G. / Pante, N. |
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履歴 | 登録 | 2017年3月14日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年3月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年9月25日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2020年1月1日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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