Entry Database : PDB / ID : 5v3q Structure visualization Downloads & linksTitle Human GSTO1-1 complexed with ML175 ComponentsGlutathione S-transferase omega-1 Details Keywords TRANSFERASE/TRANSFERASE INHIBITOR / glutathione transferase / inhibitor / ML175 / TRANSFERASE-TRANSFERASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / methylarsonate reductase / methylarsonate reductase activity / glutathione dehydrogenase (ascorbate) / glutathione dehydrogenase (ascorbate) activity / Vitamin C (ascorbate) metabolism / L-ascorbic acid metabolic process / Methylation / cellular response to arsenic-containing substance / Glutathione conjugation ... positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / methylarsonate reductase / methylarsonate reductase activity / glutathione dehydrogenase (ascorbate) / glutathione dehydrogenase (ascorbate) activity / Vitamin C (ascorbate) metabolism / L-ascorbic acid metabolic process / Methylation / cellular response to arsenic-containing substance / Glutathione conjugation / positive regulation of ryanodine-sensitive calcium-release channel activity / glutathione transferase / glutathione transferase activity / negative regulation of ryanodine-sensitive calcium-release channel activity / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / glutathione metabolic process / xenobiotic catabolic process / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / oxidoreductase activity / extracellular exosome / cytosol / cytoplasm Similarity search - Function Glutathione S-transferase, omega-class / Glutathione S-transferase Omega/Tau-like / Glutathione S-transferase, N-terminal domain / Glutathione S-transferase, N-terminal domain / Glutathione S-transferase, C-terminal domain / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Soluble glutathione S-transferase N-terminal domain profile. / Glutathione S-transferase, C-terminal-like ... Glutathione S-transferase, omega-class / Glutathione S-transferase Omega/Tau-like / Glutathione S-transferase, N-terminal domain / Glutathione S-transferase, N-terminal domain / Glutathione S-transferase, C-terminal domain / Glutathione S-transferase, C-terminal / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 - #10 / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / Soluble glutathione S-transferase N-terminal domain profile. / Glutathione S-transferase, C-terminal-like / Soluble glutathione S-transferase C-terminal domain profile. / Glutathione S-transferase, N-terminal / Glutathione S-transferase, C-terminal domain superfamily / Glutaredoxin / Glutaredoxin / Thioredoxin-like superfamily / Up-down Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.25 Å DetailsAuthors Oakley, A.J. CitationJournal : Sci Rep / Year : 2017Title : GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.Authors: Menon, D. / Innes, A. / Oakley, A.J. / Dahlstrom, J.E. / Jensen, L.M. / Brustle, A. / Tummala, P. / Rooke, M. / Casarotto, M.G. / Baell, J.B. / Nguyen, N. / Xie, Y. / Cuellar, M. / Strasser, ... Authors : Menon, D. / Innes, A. / Oakley, A.J. / Dahlstrom, J.E. / Jensen, L.M. / Brustle, A. / Tummala, P. / Rooke, M. / Casarotto, M.G. / Baell, J.B. / Nguyen, N. / Xie, Y. / Cuellar, M. / Strasser, J. / Dahlin, J.L. / Walters, M.A. / Burgio, G. / O'Neill, L.A.J. / Board, P.G. History Deposition Mar 7, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 20, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jan 3, 2018 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Apr 18, 2018 Group : Data collection / Category : diffrn_detector / Item : _diffrn_detector.detectorRevision 2.0 Apr 13, 2022 Group : Database references / Non-polymer description / Structure summaryCategory : chem_comp / database_2 / entityItem : _chem_comp.formula / _chem_comp.formula_weight ... _chem_comp.formula / _chem_comp.formula_weight / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.formula_weight Revision 2.1 Oct 4, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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