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Yorodumi- PDB-5ui4: Structure of NME1 covalently conjugated to imidazole fluorosulfate -
+Open data
-Basic information
Entry | Database: PDB / ID: 5ui4 | ||||||
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Title | Structure of NME1 covalently conjugated to imidazole fluorosulfate | ||||||
Components | Nucleoside diphosphate kinase A | ||||||
Keywords | TRANSFERASE / arylfluorosulfate / covalent / kinase | ||||||
Function / homology | Function and homology information DNA nuclease activity / Ribavirin ADME / nucleoside-diphosphate kinase / Interconversion of nucleotide di- and triphosphates / UTP biosynthetic process / CTP biosynthetic process / Azathioprine ADME / GTP biosynthetic process / nucleoside diphosphate kinase activity / positive regulation of DNA binding ...DNA nuclease activity / Ribavirin ADME / nucleoside-diphosphate kinase / Interconversion of nucleotide di- and triphosphates / UTP biosynthetic process / CTP biosynthetic process / Azathioprine ADME / GTP biosynthetic process / nucleoside diphosphate kinase activity / positive regulation of DNA binding / ribosomal small subunit binding / 3'-5' exonuclease activity / lactation / positive regulation of epithelial cell proliferation / ruffle membrane / endocytosis / nervous system development / regulation of apoptotic process / early endosome / cell differentiation / negative regulation of cell population proliferation / GTP binding / magnesium ion binding / RNA binding / extracellular exosome / ATP binding / identical protein binding / membrane / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.75 Å | ||||||
Authors | Mortenson, D.E. / Brighty, G.J. / Wilson, I.A. / Kelly, J.W. | ||||||
Funding support | United States, 1items
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Citation | Journal: J. Am. Chem. Soc. / Year: 2018 Title: "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Authors: Mortenson, D.E. / Brighty, G.J. / Plate, L. / Bare, G. / Chen, W. / Li, S. / Wang, H. / Cravatt, B.F. / Forli, S. / Powers, E.T. / Sharpless, K.B. / Wilson, I.A. / Kelly, J.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5ui4.cif.gz | 193.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5ui4.ent.gz | 155.5 KB | Display | PDB format |
PDBx/mmJSON format | 5ui4.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5ui4_validation.pdf.gz | 2.1 MB | Display | wwPDB validaton report |
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Full document | 5ui4_full_validation.pdf.gz | 2.1 MB | Display | |
Data in XML | 5ui4_validation.xml.gz | 32.7 KB | Display | |
Data in CIF | 5ui4_validation.cif.gz | 43.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ui/5ui4 ftp://data.pdbj.org/pub/pdb/validation_reports/ui/5ui4 | HTTPS FTP |
-Related structure data
Related structure data | 5uehC 2hveS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Beg auth comp-ID: PRO / Beg label comp-ID: PRO / Refine code: _
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