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- PDB-5ui4: Structure of NME1 covalently conjugated to imidazole fluorosulfate -
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Open data
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Basic information
Entry | Database: PDB / ID: 5ui4 | ||||||
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Title | Structure of NME1 covalently conjugated to imidazole fluorosulfate | ||||||
![]() | Nucleoside diphosphate kinase A | ||||||
![]() | TRANSFERASE / arylfluorosulfate / covalent / kinase | ||||||
Function / homology | ![]() DNA nuclease activity / Ribavirin ADME / nucleoside-diphosphate kinase / Interconversion of nucleotide di- and triphosphates / UTP biosynthetic process / CTP biosynthetic process / Azathioprine ADME / GTP biosynthetic process / nucleoside diphosphate kinase activity / positive regulation of DNA binding ...DNA nuclease activity / Ribavirin ADME / nucleoside-diphosphate kinase / Interconversion of nucleotide di- and triphosphates / UTP biosynthetic process / CTP biosynthetic process / Azathioprine ADME / GTP biosynthetic process / nucleoside diphosphate kinase activity / positive regulation of DNA binding / ribosomal small subunit binding / 3'-5' exonuclease activity / lactation / positive regulation of epithelial cell proliferation / ruffle membrane / endocytosis / phosphorylation / nervous system development / regulation of apoptotic process / early endosome / cell differentiation / negative regulation of cell population proliferation / GTP binding / magnesium ion binding / RNA binding / extracellular exosome / ATP binding / identical protein binding / membrane / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Mortenson, D.E. / Brighty, G.J. / Wilson, I.A. / Kelly, J.W. | ||||||
Funding support | ![]()
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![]() | ![]() Title: "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Authors: Mortenson, D.E. / Brighty, G.J. / Plate, L. / Bare, G. / Chen, W. / Li, S. / Wang, H. / Cravatt, B.F. / Forli, S. / Powers, E.T. / Sharpless, K.B. / Wilson, I.A. / Kelly, J.W. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 193.1 KB | Display | ![]() |
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PDB format | ![]() | 155.5 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 5uehC ![]() 2hveS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Beg auth comp-ID: PRO / Beg label comp-ID: PRO / Refine code: _
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