- PDB-5tzu: Crystal structure of human CD47 ECD bound to Fab of B6H12.2 -
+
Open data
ID or keywords:
Loading...
-
Basic information
Entry
Database: PDB / ID: 5tzu
Title
Crystal structure of human CD47 ECD bound to Fab of B6H12.2
Components
Heavy Chain of Fab B6H12.2
Leukocyte surface antigen CD47
Light Chain of Fab B6H12.2
Keywords
IMMUNE SYSTEM / antigen-Fab complex / immunoglobulin
Function / homology
Function and homology information
cellular response to interleukin-12 / regulation of Fc receptor mediated stimulatory signaling pathway / protein binding involved in heterotypic cell-cell adhesion / positive regulation of monocyte extravasation / regulation of type II interferon production / ATP export / positive regulation of cell-cell adhesion / regulation of interleukin-10 production / cell-cell adhesion mediator activity / regulation of tumor necrosis factor production ...cellular response to interleukin-12 / regulation of Fc receptor mediated stimulatory signaling pathway / protein binding involved in heterotypic cell-cell adhesion / positive regulation of monocyte extravasation / regulation of type II interferon production / ATP export / positive regulation of cell-cell adhesion / regulation of interleukin-10 production / cell-cell adhesion mediator activity / regulation of tumor necrosis factor production / regulation of interleukin-12 production / regulation of nitric oxide biosynthetic process / negative regulation of phagocytosis / regulation of interleukin-6 production / Signal regulatory protein family interactions / thrombospondin receptor activity / tertiary granule membrane / cellular response to interleukin-1 / Integrin cell surface interactions / specific granule membrane / positive regulation of phagocytosis / positive regulation of stress fiber assembly / integrin-mediated signaling pathway / Cell surface interactions at the vascular wall / cellular response to type II interferon / positive regulation of inflammatory response / cell migration / positive regulation of T cell activation / angiogenesis / inflammatory response / apoptotic process / positive regulation of cell population proliferation / Neutrophil degranulation / cell surface / extracellular exosome / plasma membrane Similarity search - Function
Mass: 23373.908 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293 / Production host: Homo sapiens (human)
#2: Antibody
HeavyChainofFabB6H12.2
Mass: 24196.092 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): HEK293 / Production host: Homo sapiens (human)
#3: Antibody
LeukocytesurfaceantigenCD47 / Antigenic surface determinant protein OA3 / Integrin-associated protein / IAP / Protein MER6
Mass: 14764.539 Da / Num. of mol.: 1 / Fragment: extracellular domain, UNP residues 19-141 / Mutation: C15G Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: CD47, MER6 / Cell line (production host): HEK293(GnTI-) / Production host: Homo sapiens (human) / References: UniProt: Q08722