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Structure paper

TitleAnti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies.
Journal, issue, pagesBlood Cancer J, Vol. 7, Page e536-e536, Year 2017
Publish dateNov 21, 2016 (structure data deposition date)
AuthorsPietsch, E.C. / Dong, J. / Cardoso, R. / Zhang, X. / Chin, D. / Hawkins, R. / Dinh, T. / Zhou, M. / Strake, B. / Feng, P.H. ...Pietsch, E.C. / Dong, J. / Cardoso, R. / Zhang, X. / Chin, D. / Hawkins, R. / Dinh, T. / Zhou, M. / Strake, B. / Feng, P.H. / Rocca, M. / Santos, C.D. / Shan, X. / Danet-Desnoyers, G. / Shi, F. / Kaiser, E. / Millar, H.J. / Fenton, S. / Swanson, R. / Nemeth, J.A. / Attar, R.M.
External linksBlood Cancer J / PubMed:28234345
MethodsX-ray diffraction
Resolution2.1 - 2.89 Å
Structure data

PDB-5tz2:
Crystal structure of human CD47 ECD bound to Fab of C47B222
Method: X-RAY DIFFRACTION / Resolution: 2.302 Å

PDB-5tzt:
Crystal structure of human CD47 ECD bound to Fab of C47B161
Method: X-RAY DIFFRACTION / Resolution: 2.89 Å

PDB-5tzu:
Crystal structure of human CD47 ECD bound to Fab of B6H12.2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antigen-Fab complex / immunoglobulin

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