Entry Database : PDB / ID : 5te4 Structure visualization Downloads & linksTitle Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core ComponentsHIV-1 clade G strain X2088 gp120 Heavy chain of antibody N6 Light chain of antibody N6 DetailsKeywords IMMUNE SYSTEM / HIV-1 / VRC01-class Antibody / N6 / CD4-binding site / gp120Function / homology Function and homology informationFunction Domain/homology Component
virus-mediated perturbation of host defense response => GO:0019049 / : / stimulatory C-type lectin receptor signaling pathway / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / membrane => GO:0016020 / viral protein processing ... virus-mediated perturbation of host defense response => GO:0019049 / : / stimulatory C-type lectin receptor signaling pathway / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / membrane => GO:0016020 / viral protein processing / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / structural molecule activity / virion membrane / plasma membrane Similarity search - Function HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / Immunoglobulins ... HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Human immunodeficiency virus 1Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.75 Å DetailsAuthors Zhou, T. / Kwong, P.D. CitationJournal : Immunity / Year : 2016Title : Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.Authors: Huang, J. / Kang, B.H. / Ishida, E. / Zhou, T. / Griesman, T. / Sheng, Z. / Wu, F. / Doria-Rose, N.A. / Zhang, B. / McKee, K. / O'Dell, S. / Chuang, G.Y. / Druz, A. / Georgiev, I.S. / ... Authors : Huang, J. / Kang, B.H. / Ishida, E. / Zhou, T. / Griesman, T. / Sheng, Z. / Wu, F. / Doria-Rose, N.A. / Zhang, B. / McKee, K. / O'Dell, S. / Chuang, G.Y. / Druz, A. / Georgiev, I.S. / Schramm, C.A. / Zheng, A. / Joyce, M.G. / Asokan, M. / Ransier, A. / Darko, S. / Migueles, S.A. / Bailer, R.T. / Louder, M.K. / Alam, S.M. / Parks, R. / Kelsoe, G. / Von Holle, T. / Haynes, B.F. / Douek, D.C. / Hirsch, V. / Seaman, M.S. / Shapiro, L. / Mascola, J.R. / Kwong, P.D. / Connors, M. History Deposition Sep 20, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 23, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Nov 30, 2016 Group : Database referencesRevision 1.2 Jul 29, 2020 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp / citation ... chem_comp / citation / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _citation.journal_id_CSD / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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