登録情報 | データベース: PDB / ID: 5tda |
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タイトル | Crystal structure of the UBR-box domain from UBR2 in complex with RLWS N-degron |
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要素 | - ARG-LEU-TRP-SER peptide
- E3 ubiquitin-protein ligase UBR2
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キーワード | LIGASE / Zn-finger / N-end rule / UBR-box / N-degron |
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機能・相同性 | 機能・相同性情報
histone H2A ubiquitin ligase activity / L-leucine binding / ubiquitin-dependent protein catabolic process via the N-end rule pathway / male meiotic nuclear division / retrotransposon silencing / cellular response to L-leucine / reciprocal meiotic recombination / negative regulation of TOR signaling / positive regulation of T cell receptor signaling pathway / male meiosis I ...histone H2A ubiquitin ligase activity / L-leucine binding / ubiquitin-dependent protein catabolic process via the N-end rule pathway / male meiotic nuclear division / retrotransposon silencing / cellular response to L-leucine / reciprocal meiotic recombination / negative regulation of TOR signaling / positive regulation of T cell receptor signaling pathway / male meiosis I / protein K63-linked ubiquitination / ubiquitin ligase complex / RING-type E3 ubiquitin transferase / heterochromatin formation / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / spermatogenesis / proteasome-mediated ubiquitin-dependent protein catabolic process / protein ubiquitination / chromatin / zinc ion binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 : / E3 ubiquitin-protein ligase ELL-like / E3 ubiquitin-protein ligase UBR-like, C-terminal / Proteolysis_6 C-terminal / E3 ubiquitin-protein ligase UBR1-like / Putative zinc finger in N-recognin (UBR box) / Adaptor protein ClpS, core / ATP-dependent Clp protease adaptor protein ClpS / Zinc finger, UBR-type / Zinc finger UBR-type profile. ...: / E3 ubiquitin-protein ligase ELL-like / E3 ubiquitin-protein ligase UBR-like, C-terminal / Proteolysis_6 C-terminal / E3 ubiquitin-protein ligase UBR1-like / Putative zinc finger in N-recognin (UBR box) / Adaptor protein ClpS, core / ATP-dependent Clp protease adaptor protein ClpS / Zinc finger, UBR-type / Zinc finger UBR-type profile. / Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway / Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like / Winged helix DNA-binding domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 0.79 Å |
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データ登録者 | Munoz-Escobar, J. / Kozlov, G. / Gehring, K. |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Canadian Institutes of Health Research (CIHR) | | カナダ |
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引用 | |
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履歴 | 登録 | 2016年9月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年3月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年4月26日 | Group: Database references |
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改定 1.2 | 2017年5月10日 | Group: Database references |
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改定 1.3 | 2017年9月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2020年1月8日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id |
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