PDB-5s50: Tubulin-Z57299526-complex

ID or keywords:

Entry

Database: PDB / ID: 5s50

Title

Tubulin-Z57299526-complex

Components

Stathmin-4
Tubulin alpha-1B chain
Tubulin beta-2B chain
Tubulin-Tyrosine Ligase

Keywords

CELL CYCLE / TUBULIN FOLD / CYTOSKELETON / MICROTUBULE

Function / homology

Function and homology information

tubulin-tyrosine ligase activity / positive regulation of axon guidance / microtubule depolymerization / microtubule-based process / regulation of microtubule polymerization or depolymerization / tubulin binding / spindle microtubule / protein modification process / structural constituent of cytoskeleton / microtubule cytoskeleton organization ...
Similarity search - Function

Biological species

Rattus norvegicus (Norway rat)

Gallus gallus (chicken)

Bos taurus (cattle)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

FOURIER SYNTHESIS / Resolution: 3.1 Å

Authors

Muehlethaler, T. / Gioia, D. / Prota, A.E. / Sharpe, M.E. / Cavalli, A. / Steinmetz, M.O.

Funding support

European Union,

Italy,

Switzerland, 4items

Organization	Grant number	Country
iNEXT/Horizon 2020	PID2692	European Union
NEON/Regione Lombardia	ID239047	Italy
Swiss National Science Foundation	31003A_166608	Switzerland
Swiss National Science Foundation	31030A_192566	Switzerland

Citation

Journal: Angew.Chem.Int.Ed.Engl. / Year: 2021
Title: Comprehensive Analysis of Binding Sites in Tubulin.
Authors: Muhlethaler, T. / Gioia, D. / Prota, A.E. / Sharpe, M.E. / Cavalli, A. / Steinmetz, M.O.

History

Deposition	Nov 8, 2020	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Jun 30, 2021	Provider: repository / Type: Initial release
Revision 1.1	Mar 6, 2024	Group: Advisory / Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	5s50.cif.gz	922.1 KB	Display	PDBx/mmCIF format
PDB format	pdb5s50.ent.gz	763.6 KB	Display	PDB format
PDBx/mmJSON format	5s50.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Summary document	5s50_validation.pdf.gz	2.1 MB	Display	wwPDB validaton report
Full document	5s50_full_validation.pdf.gz	2.1 MB	Display
Data in XML	5s50_validation.xml.gz	82.4 KB	Display
Data in CIF	5s50_validation.cif.gz	107.4 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/s5/5s50 ftp://data.pdbj.org/pub/pdb/validation_reports/s5/5s50	HTTPS FTP

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Group deposition

ID	G_1002173 (59 entries) 5s4l 5s4m 5s4n 5s4o 5s4p 5s4q 5s4r 5s4s 5s4t 5s4u
Title	XChem fragment screening on T2R-TTL
Type	undefined
Description	Crystal structures of Tubulin-XChem-fragment complexes

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Related structure data

Related structure data	5lxtS S: Starting model for refinement
Similar structure data	5s5g-d 5s5p-d 5s5s-d 7daf-d 5s5n-d 5s63-d 6d88-d 5s5h-d 5s65-d 5s5f-d 5lxs-d 6s9e-d 5xkf-d 6bs2-d 5s5y-d 6y4n-d 6hx8-d 4o2a-d 6nng-d 6fii-d Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#175 - Jul 2014 Microtubules similarity (28) #176 - Aug 2014 Dynein similarity (19) #241 - Jan 2020 Twenty Years of Molecules similarity (19) #118 - Oct 2009 Sodium-Potassium Pump similarity (1) #168 - Dec 2013 DNA Helicase similarity (1) #195 - Mar 2016 RAF Protein Kinases similarity (1)

Deposited unit

A: Tubulin alpha-1B chain

B: Tubulin beta-2B chain

C: Tubulin alpha-1B chain

D: Tubulin beta-2B chain

E: Stathmin-4

F: Tubulin-Tyrosine Ligase

hetero molecules

265 kDa, 6 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

Idetical with deposited unit
defined by author

Unit cell

Length a, b, c (Å)	104.030, 158.020, 180.880
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	19
Space group name H-M	P2₁2₁2₁

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Protein , 4 types, 6 molecules ACBDEF

#1: Protein	Tubulin alpha-1B chain / Alpha-tubulin ubiquitous / Tubulin K-alpha-1 / Tubulin alpha-ubiquitous chain Mass: 50204.445 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Bos taurus (cattle) / Organ: Brain / References: UniProt: P81947
#2: Protein	Tubulin beta-2B chain Mass: 49999.887 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Bos taurus (cattle) / Organ: Brain / References: UniProt: Q6B856
#3: Protein	Stathmin-4 / Stathmin-like protein B3 / RB3 Mass: 16844.162 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Rattus norvegicus (Norway rat) / Gene: Stmn4 / Production host: Escherichia coli (E. coli) / References: UniProt: P63043
#4: Protein	Tubulin-Tyrosine Ligase Mass: 44378.496 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Gallus gallus (chicken) / Gene: TTL / Production host: Escherichia coli (E. coli) / References: UniProt: E1BQ43

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Non-polymers , 8 types, 40 molecules

#5: Chemical	ChemComp-GTP / GUANOSINE-5'-TRIPHOSPHATE Mass: 523.180 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₁₀H₁₆N₅O₁₄P₃ / Comment: GTP, energy-carrying molecule*YM
#6: Chemical	ChemComp-MG / MAGNESIUM ION Mass: 24.305 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: Mg
#7: Chemical	ChemComp-CA / CALCIUM ION Mass: 40.078 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Ca
#8: Chemical	ChemComp-GDP / GUANOSINE-5'-DIPHOSPHATE Type: RNA linking / Mass: 443.201 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₁₀H₁₅N₅O₁₁P₂ / Comment: GDP, energy-carrying molecule*YM
#9: Chemical	ChemComp-MES / 2-(N-MORPHOLINO)-ETHANESULFONIC ACID Mass: 195.237 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₆H₁₃NO₄S / Comment: pH buffer*YM
#10: Chemical	ChemComp-WZD / N-[(furan-2-yl)methyl]-1H-benzimidazol-2-amine Mass: 213.235 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₁₂H₁₁N₃O / Feature type: SUBJECT OF INVESTIGATION
#11: Chemical	ChemComp-ACP / PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / ADENOSINE-5'-[BETA, GAMMA-METHYLENE]TRIPHOSPHATE Mass: 505.208 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₁₁H₁₈N₅O₁₂P₃ / Comment: AMP-PCP, energy-carrying molecule analogue*YM
#12: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 23 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	Y

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.8 Å³/Da / Density % sol: 56.6 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 6.5 Details: 2% PEG 4K, 4% glycerol, 30 mM MgCl2, 30 mM CaCl2, 0.1 M MES/Imidazole, 5 mM L-tyrosine

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Data collection

Diffraction

Mean temperature: 100 K

Diffraction source

Source:

SYNCHROTRON / Site:

Diamond

/ Beamline: I04-1 / Wavelength: 0.91587 Å

Detector

Type: DECTRIS PILATUS 6M-F / Detector: PIXEL / Date: Feb 14, 2018

Radiation

Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray

Radiation wavelength

Wavelength: 0.91587 Å / Relative weight: 1

Reflection

Resolution: 3.1→79.01 Å / Num. obs: 54710 / % possible obs: 99.8 % / Redundancy: 6.71 % / B_iso Wilson estimate: 106.964 Å² / CC_1/2: 0.999 / R_merge(I) obs: 0.088 / R_rim(I) all: 0.096 / Χ²: 0.981 / Net I/σ(I): 14.78 / Num. measured all: 367126 / Scaling rejects: 181

Reflection shell

Diffraction-ID: 1

Resolution (Å)	Redundancy (%)	R_merge(I) obs	Mean I/σ(I) obs	Num. measured obs	Num. possible	Num. unique obs	CC_1/2	R_rim(I) all	% possible all
3.1-3.18	6.956	2.273	0.84	27658	3986	3976	0.405	2.456	99.7
3.18-3.27	6.902	1.714	1.12	27167	3948	3936	0.534	1.853	99.7
3.27-3.36	6.716	1.261	1.52	25446	3798	3789	0.672	1.367	99.8
3.36-3.47	6.342	0.905	2.04	23193	3663	3657	0.762	0.987	99.8
3.47-3.58	6.628	0.698	2.69	23807	3603	3592	0.858	0.758	99.7
3.58-3.71	6.632	0.501	3.77	22649	3439	3415	0.91	0.543	99.3
3.71-3.85	7.138	0.335	5.65	24054	3381	3370	0.968	0.361	99.7
3.85-4	7.086	0.236	7.85	22726	3212	3207	0.983	0.255	99.8
4-4.18	6.992	0.162	10.96	21640	3096	3095	0.99	0.175	100
4.18-4.38	6.903	0.115	14.14	20460	2969	2964	0.995	0.124	99.8
4.38-4.62	6.782	0.08	19.48	19098	2824	2816	0.997	0.087	99.7
4.62-4.9	6.488	0.069	21.87	17361	2679	2676	0.998	0.075	99.9
4.9-5.24	6.123	0.065	22.6	15553	2542	2540	0.997	0.071	99.9
5.24-5.66	6.451	0.064	23.85	15167	2353	2351	0.998	0.069	99.9
5.66-6.2	6.972	0.057	27.45	15144	2174	2172	0.998	0.062	99.9
6.2-6.93	6.845	0.047	32.8	13751	2008	2009	0.999	0.051	100
6.93-8	6.552	0.033	42.32	11511	1757	1757	0.999	0.036	100
8-9.8	5.977	0.023	57.09	8948	1503	1497	1	0.025	99.6
9.8-13.86	6.254	0.02	68.37	7517	1203	1202	0.999	0.022	99.9
13.86-79.01	6.206	0.019	73.42	4276	707	689	0.999	0.021	97.5

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Processing

Software

Name	Version	Classification
PHENIX	1.18.2_3874	refinement
XSCALE		data scaling
PDB_EXTRACT	3.27	data extraction
XDS		data reduction
PHENIX	1.18.2_3874	phasing

Refinement

Method to determine structure:

FOURIER SYNTHESIS
Starting model: 5lxt

5lxt

Resolution: 3.1→79.01 Å / SU ML: 0.53 / Cross valid method: THROUGHOUT / σ(F): 1.35 / Phase error: 32.03 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2697	2691	4.92 %
R_work	0.2076	52002	-
obs	0.2107	54693	99.72 %

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso max: 302.01 Å² / B_iso mean: 136.4036 Å² / B_iso min: 70.27 Å²

Refinement step

Cycle: final / Resolution: 3.1→79.01 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	17416	0	226	23	17665
B_iso mean	-	-	126.08	109.65	-
Num. residues	-	-	-	-	2201

LS refinement shell

Refine-ID: X-RAY DIFFRACTION / R_factor R_free error: 0 / Total num. of bins used: 19

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Num. reflection all	% reflection obs (%)
3.1-3.16	0.403	149	0.3805	2717	2866	100
3.16-3.22	0.4299	126	0.3553	2699	2825	100
3.22-3.28	0.3945	143	0.341	2682	2825	100
3.28-3.35	0.3898	143	0.3111	2717	2860	100
3.35-3.43	0.3543	127	0.2957	2709	2836	100
3.43-3.52	0.3293	141	0.2856	2678	2819	100
3.52-3.61	0.3512	152	0.2844	2718	2870	100
3.61-3.72	0.368	115	0.3091	2716	2831	99
3.72-3.84	0.3106	164	0.2309	2690	2854	100
3.84-3.98	0.2556	138	0.225	2711	2849	100
3.98-4.14	0.2394	130	0.2059	2734	2864	100
4.14-4.32	0.2604	142	0.2019	2740	2882	100
4.32-4.55	0.2244	128	0.1834	2737	2865	100
4.55-4.84	0.2347	132	0.1732	2748	2880	100
4.84-5.21	0.264	152	0.181	2755	2907	100
5.21-5.73	0.2987	130	0.196	2777	2907	100
5.73-6.56	0.272	174	0.2082	2756	2930	100
6.57-8.27	0.274	142	0.1857	2812	2954	100
8.27-79.01	0.2199	163	0.1665	2906	3069	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	2.1028	0.5333	0.7224	5.4231	0.5722	3.1822	0.0306	0.5846	0.3488	-0.9205	0.3436	-0.6973	-0.8556	0.3381	-0.417	1.2377	-0.2213	0.2703	1.0705	-0.2943	1.1799	31.958	89.9577	50.5076
2	2.86	-1.3441	-2.304	8.1611	1.0536	6.5159	-0.0697	-0.6264	-0.0796	0.9633	0.4178	-0.3705	0.6286	1.6696	-0.2242	1.0323	-0.0171	0.0552	1.1274	-0.2814	1.0836	29.854	74.5287	58.772
3	2.6387	0.9917	1.1138	5.1502	-0.1248	7.8505	0.1856	-0.0956	0.1294	0.0045	0.0613	0.3088	-0.64	-0.3749	-0.3006	0.8731	0.0957	0.1563	0.9198	-0.2699	0.995	16.593	84.7825	66.4548
4	1.8774	-1.1976	-0.083	8.8203	2.4051	2.7255	-0.5759	-0.3369	0.0452	1.656	0.8507	0.2091	0.3022	0.182	-0.2481	1.1978	0.1067	0.1519	1.1569	-0.2489	1.0643	18.692	83.6869	73.014
5	1.9249	1.5106	0.9811	3.6952	3.1754	8.7307	0.0155	-0.7188	0.1175	0.7026	0.7118	-0.404	1.2447	1.5708	-0.875	1.0962	0.3068	-0.1312	1.3931	-0.4264	1.3288	32.2061	62.4426	61.4774
6	7.0187	-2.7209	-0.2655	8.3639	1.6481	7.5705	0.2041	0.2753	0.8161	-1.0692	-0.2834	0.2566	-1.443	-0.5963	0.0577	1.0823	0.0875	0.0264	1.0859	-0.0791	1.0673	15.8692	70.3671	18.7907
7	2.197	-0.7632	-1.0709	3.8418	1.7374	6.6714	0.0636	0.1215	0.1858	-0.3418	-0.0097	-0.0041	-0.4512	-0.1525	-0.0405	0.668	0.0647	0.0267	0.7145	-0.1772	0.8817	20.0598	56.5348	25.0495
8	5.9219	-4.2017	2.9309	5.6403	-0.4072	4.8481	-0.1117	-0.66	0.2548	0.0674	-0.0592	0.4114	-0.0243	-1.5517	0.1365	0.9356	0.044	0.1245	1.4448	-0.4239	1.0607	5.4184	60.3934	41.9849
9	0.9734	-1.6483	-2.3003	5.4383	3.7803	5.9107	-0.3087	-0.1949	0.0581	1.1875	0.1239	0.1296	1.0183	0.3482	0.1757	0.9756	-0.0917	0.0324	0.9718	-0.1138	1.0742	20.8298	42.246	31.2014
10	3.6137	-0.9945	0.1776	6.055	0.1095	3.8915	0.004	0.4653	0.2261	-0.314	0.0265	-0.2614	-0.1966	0.2697	-0.051	0.8019	-0.2027	0.0643	0.9117	-0.0178	0.8146	20.5155	32.8187	-11.9071
11	2.9147	-1.6683	0.4261	3.984	1.0868	4.7347	-0.0522	-0.0863	-0.0811	0.0746	0.0168	0.2924	0.131	-0.4436	0.0119	0.7745	-0.2176	0.1306	0.8642	-0.0527	0.9235	8.1496	25.972	3.3015
12	8.1845	-2.6393	0.2974	6.3905	-1.4213	3.6503	-0.0783	0.9254	0.1885	-1.1626	0.1288	0.2747	0.1378	-0.4266	-0.0086	1.5044	-0.4735	0.1018	1.7683	-0.1604	1.1207	17.2564	8.8173	-44.0146
13	3.4846	-0.451	-1.3086	2.8278	0.4158	2.9438	-0.5105	1.3522	-0.6033	-0.5642	0.3451	-0.1351	0.4027	-0.3012	0.1469	1.242	-0.283	0.1269	1.4388	-0.3398	0.9448	22.9601	-2.7456	-33.8648
14	3.1975	-3.2694	-1.8772	6.5736	-0.319	2.8708	1.1683	0.6646	-1.0228	-0.8336	-0.1353	1.1062	0.4507	0.5769	-0.8789	1.7442	-0.2568	-0.1538	1.9463	-0.5221	1.4026	0.8645	-6.6392	-25.2596
15	3.8671	-0.9761	0.9311	2.927	-2.0829	3.6038	-0.3916	-0.3249	-0.2294	0.3676	0.7221	0.1568	-0.3462	-0.6714	-0.3802	1.4299	-0.3064	0.089	1.4406	-0.2811	1.2169	8.9182	-2.1937	-20.4433
16	6.1662	-0.6868	-4.7188	3.5837	0.4931	6.1733	-0.332	-0.6023	-1.268	-0.1516	0.3994	0.0137	0.651	1.2083	-0.2329	1.6505	0.1421	0.0605	1.3474	-0.4207	1.6391	30.7795	-17.5069	-23.7971
17	7.8281	-2.8794	-3.415	6.8025	4.0817	5.4252	-0.623	-1.1076	0.9133	1.9303	0.499	-0.4414	1.0631	1.0982	0.0199	1.5527	0.0654	-0.2461	1.5225	-0.3181	1.273	27.2405	93.4049	81.7045
18	0.4042	0.0084	-0.3486	4.4544	4.9384	4.8961	-0.3943	-0.0956	0.0512	1.2256	0.7251	-0.1217	1.3905	1.3639	-0.2236	1.3746	0.1309	0.0446	1.2086	-0.3157	1.3089	43.2343	28.1727	4.1861
19	6.0839	1.5708	-1.4393	5.8041	0.9999	4.6515	-0.5434	0.6858	-0.5106	-0.458	0.8305	-0.165	0.746	-0.5524	-0.2679	1.8502	-0.3258	0.2687	1.5032	-0.1606	1.3756	6.3274	54.887	69.4291
20	8.5379	-0.9675	3.2168	4.1584	-2.3829	4.9436	0.3719	-0.4434	0.8983	-0.1013	-0.0166	-0.1285	-1.286	0.0052	-0.4403	1.5373	-0.0261	0.027	1.4842	0.073	1.0825	16.5907	64.2945	102.393
21	2.8113	1.1503	0.8038	2.9398	0.1697	4.0151	-0.1672	-0.4944	-0.785	0.3822	0.3757	-0.3511	1.1398	0.6602	-0.02	1.8965	0.3737	0.171	1.2891	-0.0825	1.2654	11.6197	52.4809	105.4119
22	2.4463	1.6127	-0.4381	2.6826	0.8632	3.8738	-0.4239	0.4204	-1.0107	0.4489	0.328	-0.5187	1.165	0.0669	0.0421	1.9505	0.1524	0.3656	1.1754	-0.082	1.563	-2.0645	49.9097	99.1505
23	3.5626	0.4784	-0.0841	1.7404	0.5314	6.1749	-0.2965	0.1761	-0.7453	-0.2439	0.7021	0.1117	0.9465	-0.5385	-0.3493	2.1649	-0.0705	0.4272	1.0712	-0.0478	1.2389	0.9929	58.3173	87.3867
24	4.8658	-1.9525	-1.9474	4.0748	1.7372	9.0276	0.0818	0.8874	0.9443	-0.415	0.1499	0.7396	-0.6975	0.5455	-0.3743	1.3728	-0.25	0.2092	1.2246	-0.1483	1.4028	-7.9331	63.5211	79.2127

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 1 through 160 )	A	1 - 160
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 161 through 199 )	A	161 - 199
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 200 through 311 )	A	200 - 311
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 312 through 401 )	A	312 - 401
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 402 through 438 )	A	402 - 438
6	X-RAY DIFFRACTION	6	chain 'B' and (resid 1 through 88 )	B	1 - 88
7	X-RAY DIFFRACTION	7	chain 'B' and (resid 89 through 259 )	B	89 - 259
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 260 through 372 )	B	260 - 372
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 373 through 438 )	B	373 - 438
10	X-RAY DIFFRACTION	10	chain 'C' and (resid 1 through 197 )	C	1 - 197
11	X-RAY DIFFRACTION	11	chain 'C' and (resid 198 through 440 )	C	198 - 440
12	X-RAY DIFFRACTION	12	chain 'D' and (resid 1 through 88 )	D	1 - 88
13	X-RAY DIFFRACTION	13	chain 'D' and (resid 89 through 273 )	D	89 - 273
14	X-RAY DIFFRACTION	14	chain 'D' and (resid 274 through 311 )	D	274 - 311
15	X-RAY DIFFRACTION	15	chain 'D' and (resid 312 through 399 )	D	312 - 399
16	X-RAY DIFFRACTION	16	chain 'D' and (resid 400 through 441 )	D	400 - 441
17	X-RAY DIFFRACTION	17	chain 'E' and (resid 6 through 46 )	E	6 - 46
18	X-RAY DIFFRACTION	18	chain 'E' and (resid 47 through 143 )	E	47 - 143
19	X-RAY DIFFRACTION	19	chain 'F' and (resid 1 through 66 )	F	1 - 66
20	X-RAY DIFFRACTION	20	chain 'F' and (resid 67 through 140 )	F	67 - 140
21	X-RAY DIFFRACTION	21	chain 'F' and (resid 141 through 207 )	F	141 - 207
22	X-RAY DIFFRACTION	22	chain 'F' and (resid 208 through 297 )	F	208 - 297
23	X-RAY DIFFRACTION	23	chain 'F' and (resid 298 through 354 )	F	298 - 354
24	X-RAY DIFFRACTION	24	chain 'F' and (resid 355 through 382 )	F	355 - 382

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