- PDB-5oay: M. tuberculosis [4Fe-4S] protein WhiB1 is a four-helix bundle tha... -
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Basic information
Entry
Database: PDB / ID: 5oay
Title
M. tuberculosis [4Fe-4S] protein WhiB1 is a four-helix bundle that forms a NO-sensitive complex with sigmaA and regulates the major virulence factor ESX-1
Components
Transcriptional regulator WhiB1
Keywords
SIGNALING PROTEIN / nitric oxide / sigmaA / iron-sulfur / tuberculosis / Wbl protein
Function / homology
Function and homology information
dinitrosyl-iron complex binding / protein-disulfide reductase (NAD(P)H) activity / response to nitric oxide / protein-disulfide reductase activity / cell redox homeostasis / 4 iron, 4 sulfur cluster binding / negative regulation of DNA-templated transcription / DNA binding / metal ion binding / cytoplasm Similarity search - Function
BMRB: 34153M. tuberculosis [4Fe-4S] protein WhiB1 is a four-helix bundle that forms a NO-sensitive complex with sigmaA and regulates the major virulence factor ESX-1
Evidence: mass spectrometry, Assembly is partly paramagnetic
Type
Name
Symmetry operation
Number
identity operation
1_555
1
Buried area
370 Å2
ΔGint
-21 kcal/mol
Surface area
5240 Å2
Method
PISA
NMR ensembles
Data
Criteria
Number of conformers (submitted / calculated)
10 / 62
structures with the lowest energy
Representative
Model #1
lowest energy
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Components
#1: Protein
TranscriptionalregulatorWhiB1
Mass: 10383.681 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: The sequence provided begins 9 residues before the start of the folded protein Source: (gene. exp.) Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (bacteria) Gene: whiB1, Rv3219 / Production host: Mycobacterium smegmatis (bacteria) / References: UniProt: P9WF43
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