登録情報 | データベース: PDB / ID: 5o2q |
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タイトル | p130Cas SH3 domain Vinculin peptide chimera |
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要素 | Breast cancer anti-estrogen resistance 1,Vinculin |
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キーワード | STRUCTURE FROM CYANA 3.97 / SH3 domain / p130Cas |
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機能・相同性 | 機能・相同性情報
antigen receptor-mediated signaling pathway / endothelin receptor signaling pathway / hepatocyte growth factor receptor signaling pathway / cellular response to hepatocyte growth factor stimulus / p130Cas linkage to MAPK signaling for integrins / neurotrophin TRK receptor signaling pathway / platelet-derived growth factor receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / cell surface receptor protein tyrosine kinase signaling pathway ...antigen receptor-mediated signaling pathway / endothelin receptor signaling pathway / hepatocyte growth factor receptor signaling pathway / cellular response to hepatocyte growth factor stimulus / p130Cas linkage to MAPK signaling for integrins / neurotrophin TRK receptor signaling pathway / platelet-derived growth factor receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / cell surface receptor protein tyrosine kinase signaling pathway / ruffle / positive regulation of endothelial cell migration / Downstream signal transduction / cell chemotaxis / actin filament organization / integrin-mediated signaling pathway / regulation of cell growth / adherens junction / B cell receptor signaling pathway / epidermal growth factor receptor signaling pathway / sarcolemma / VEGFA-VEGFR2 Pathway / SH3 domain binding / actin filament binding / actin cytoskeleton / cell migration / insulin receptor signaling pathway / lamellipodium / T cell receptor signaling pathway / regulation of apoptotic process / cytoskeleton / cell adhesion / positive regulation of cell migration / G protein-coupled receptor signaling pathway / cell division / axon / focal adhesion / protein kinase binding / membrane / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 : / BCAR1, SH3 domain / Serine rich protein interaction domain / CAS family, C-terminal / CAS family / CAS, serine rich four helix bundle domain superfamily / Serine rich protein interaction domain / Crk-Associated Substrate C-terminal domain / Vinculin / Vinculin/alpha-catenin ...: / BCAR1, SH3 domain / Serine rich protein interaction domain / CAS family, C-terminal / CAS family / CAS, serine rich four helix bundle domain superfamily / Serine rich protein interaction domain / Crk-Associated Substrate C-terminal domain / Vinculin / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / SH3 domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain類似検索 - ドメイン・相同性 Metavinculin / Breast cancer anti-estrogen resistance protein 1 / Breast cancer anti-estrogen resistance 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Hexnerova, R. / Veverka, V. |
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引用 | ジャーナル: Sci Rep / 年: 2017 タイトル: Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. 著者: Gemperle, J. / Hexnerova, R. / Lepsik, M. / Tesina, P. / Dibus, M. / Novotny, M. / Brabek, J. / Veverka, V. / Rosel, D. |
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履歴 | 登録 | 2017年5月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年9月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月8日 | Group: Data collection / カテゴリ: pdbx_nmr_software / Item: _pdbx_nmr_software.name |
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改定 1.2 | 2019年10月30日 | Group: Data collection / Database references / カテゴリ: pdbx_database_related / pdbx_nmr_spectrometer / Item: _pdbx_nmr_spectrometer.model |
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改定 1.3 | 2024年6月19日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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