Entry Database : PDB / ID : 5nzw Structure visualization Downloads & linksTitle Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxone ComponentsDNA cross-link repair 1A protein Details Keywords DNA BINDING PROTEIN / exonulcease / cephalosporin / cross-link repair / DCLRE1AFunction / homology Function and homology informationFunction Domain/homology Component
5'-3' DNA exonuclease activity / interstrand cross-link repair / Fanconi Anemia Pathway / fibrillar center / double-strand break repair via nonhomologous end joining / beta-lactamase activity / beta-lactamase / damaged DNA binding / cell cycle / cell division ... 5'-3' DNA exonuclease activity / interstrand cross-link repair / Fanconi Anemia Pathway / fibrillar center / double-strand break repair via nonhomologous end joining / beta-lactamase activity / beta-lactamase / damaged DNA binding / cell cycle / cell division / nucleoplasm / metal ion binding Similarity search - Function Rossmann fold - #12650 / DNA repair metallo-beta-lactamase / DNA repair metallo-beta-lactamase / Rad18, zinc finger UBZ4-type / Zinc finger UBZ4-type profile. / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / Metallo-beta-lactamase; Chain A / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / 4-Layer Sandwich / Rossmann fold ... Rossmann fold - #12650 / DNA repair metallo-beta-lactamase / DNA repair metallo-beta-lactamase / Rad18, zinc finger UBZ4-type / Zinc finger UBZ4-type profile. / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / Metallo-beta-lactamase; Chain A / Ribonuclease Z/Hydroxyacylglutathione hydrolase-like / 4-Layer Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Newman, J.A. / Aitkenhead, H. / Kupinska, K. / Burgess-Brown, N.A. / Talon, R. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Bountra, C. / Gileadi, O. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Wellcome Trust United Kingdom
CitationJournal : To Be Published Title : Crystal structure of DNA cross-link repair protein 1A in complex with ceftriaxoneAuthors : Newman, J.A. / Aitkenhead, H. / Kupinska, K. / Burgess-Brown, N.A. / Talon, R. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. / Edwards, A. / Bountra, C. / Gileadi, O. History Deposition May 15, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 14, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 23, 2017 Group : Author supporting evidence / Refinement description / Category : pdbx_audit_support / refine_histItem : _pdbx_audit_support.funding_organization / _refine_hist.d_res_lowRevision 1.2 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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