Entry | Database: PDB / ID: 5nz1 |
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Title | Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with sutezolid |
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Components | HTH-type transcriptional regulator EthR |
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Keywords | TRANSCRIPTION / EthR / represor / boosting effect |
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Function / homology | Function and homology information
transcription cis-regulatory region binding / DNA-binding transcription factor activity / response to antibiotic / negative regulation of DNA-templated transcription / regulation of DNA-templated transcription / cytosolSimilarity search - Function : / Transcriptional regulator EthR, C-terminal domain / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. / Homeodomain-like / Homeobox-like domain superfamily ...: / Transcriptional regulator EthR, C-terminal domain / Tetracycline Repressor, domain 2 / Tetracyclin repressor-like, C-terminal domain superfamily / Tetracycline Repressor; domain 2 / Bacterial regulatory proteins, tetR family / DNA-binding HTH domain, TetR-type / TetR-type HTH domain profile. / Homeodomain-like / Homeobox-like domain superfamily / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.33 Å |
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Authors | Mendes, V. / Blaszczyk, M. / Nikiforov, P.O. / Blundell, T.L. |
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Funding support | United States, 1items Organization | Grant number | Country |
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Bill & Melinda Gates Foundation | | United States |
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Citation | Journal: To Be Published Title: The antibiotics linezolid and sutezolid are ligands for Mycobacterium tuberculosis EthR Authors: Nikiforov, P.O. / Blaszczyk, M. / Mendes, V. / Boshoff, H.I. / Barry, C.E. / Blundell, T.L. / Abell, C. |
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History | Deposition | May 12, 2017 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | May 30, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 17, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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